Abstract
Most solid tumors are angiogenesis dependent. Anti-angiogenic pharmaceuticals that inhibit the growth of new blood vessels offer considerable promise as anti-cancer agents. With increasing numbers of antiangiogenic drugs in clinical trials, there is an urgent need for detailed characterization of the heterogeneity of tumor vasculature and dissection of the complex network of mechanisms that control tumor angiogenesis. Non-invasive molecular imaging will play a key role in individualized anti-angiogenic therapy based upon molecular features of the new blood vessel growth. Integrin αvβ3, which binds several ligands via an RGD tripeptide sequence, is uniquely expressed in tumor vasculature and aggressive tumor cells, making it a potential target for anti-angiogenic interventions. This review highlights some recent advances in multimodality imaging of tumor integrin expression with emphasis on positron emission tomography (PET).
Keywords: Tumor angiogenesis, molecular imaging, integrin αvβ3, RGD peptide, positron emission tomography (PET)
Mini-Reviews in Medicinal Chemistry
Title: Multimodality Imaging of Tumor Integrin αvβ3 Expression
Volume: 6 Issue: 2
Author(s): Xiaoyuan Chen
Affiliation:
Keywords: Tumor angiogenesis, molecular imaging, integrin αvβ3, RGD peptide, positron emission tomography (PET)
Abstract: Most solid tumors are angiogenesis dependent. Anti-angiogenic pharmaceuticals that inhibit the growth of new blood vessels offer considerable promise as anti-cancer agents. With increasing numbers of antiangiogenic drugs in clinical trials, there is an urgent need for detailed characterization of the heterogeneity of tumor vasculature and dissection of the complex network of mechanisms that control tumor angiogenesis. Non-invasive molecular imaging will play a key role in individualized anti-angiogenic therapy based upon molecular features of the new blood vessel growth. Integrin αvβ3, which binds several ligands via an RGD tripeptide sequence, is uniquely expressed in tumor vasculature and aggressive tumor cells, making it a potential target for anti-angiogenic interventions. This review highlights some recent advances in multimodality imaging of tumor integrin expression with emphasis on positron emission tomography (PET).
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Cite this article as:
Chen Xiaoyuan, Multimodality Imaging of Tumor Integrin αvβ3 Expression, Mini-Reviews in Medicinal Chemistry 2006; 6 (2) . https://dx.doi.org/10.2174/138955706775475975
DOI https://dx.doi.org/10.2174/138955706775475975 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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