Abstract
A review of neurochemical research on classical neurotransmitters, i.e. acetylcholine, serotonin, noradrenaline, dopamine, glutamate, and GABA in Alzheimers disease is presented. Findings are linked to the information processing system of the human brain to establish a more functional neurochemistry. On this basis, different pharmacotherapeutic strategies are discussed. Our conclusion is that current symptomatic therapy of Alzheimers disease is insufficient. Besides therapy with acetylcholineesterase inhibitors, comedication to act on imbalances between serotonin and noradrenaline on the one site, and dopamine, glutamate and GABA on the other site should should be considered.
Keywords: Neurochemistry, acetylcholineesterase, serotonin, dopamine, glutamate, GABA, noradrenaline
Current Pharmaceutical Design
Title: Functional Neurochemistry of Alzheimers Disease
Volume: 10 Issue: 3
Author(s): Wieland Gsell, Gerd Jungkunz and Peter Riederer
Affiliation:
Keywords: Neurochemistry, acetylcholineesterase, serotonin, dopamine, glutamate, GABA, noradrenaline
Abstract: A review of neurochemical research on classical neurotransmitters, i.e. acetylcholine, serotonin, noradrenaline, dopamine, glutamate, and GABA in Alzheimers disease is presented. Findings are linked to the information processing system of the human brain to establish a more functional neurochemistry. On this basis, different pharmacotherapeutic strategies are discussed. Our conclusion is that current symptomatic therapy of Alzheimers disease is insufficient. Besides therapy with acetylcholineesterase inhibitors, comedication to act on imbalances between serotonin and noradrenaline on the one site, and dopamine, glutamate and GABA on the other site should should be considered.
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Cite this article as:
Gsell Wieland, Jungkunz Gerd and Riederer Peter, Functional Neurochemistry of Alzheimers Disease, Current Pharmaceutical Design 2004; 10 (3) . https://dx.doi.org/10.2174/1381612043386473
DOI https://dx.doi.org/10.2174/1381612043386473 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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