Abstract
Magnetic resonance imaging (MRI) contrast agents are utilized adjunctively to enhance the contrast between normal and abnormal structures on MRI scans. Along with the rapid evolution of the field has come a new appreciation for the medicinal chemistry of this unique class of metallopharmaceuticals. The efficacy of MRI agents is a complex function of chemical, biophysical, and pharmacological properties, which must be married in a package of exquisite safety. This report illustrates the wide range of medicinal chemistry relevant to existing agents that are either approved or in clinical development, as well as concepts, which may result in exciting new pharmaceuticals in the future.
Keywords: mri, contrast agents, gadolinium, extracellular contrast agents, liver contrast agents, vascular contrast agents (blood pool contrast agents)
Current Medicinal Chemistry
Title: Gadolinium Meets Medicinal Chemistry: MRI Contrast Agent Development
Volume: 12 Issue: 7
Author(s): Zhaoda Zhang, Shrikumar A. Nair and Thomas J. McMurry
Affiliation:
Keywords: mri, contrast agents, gadolinium, extracellular contrast agents, liver contrast agents, vascular contrast agents (blood pool contrast agents)
Abstract: Magnetic resonance imaging (MRI) contrast agents are utilized adjunctively to enhance the contrast between normal and abnormal structures on MRI scans. Along with the rapid evolution of the field has come a new appreciation for the medicinal chemistry of this unique class of metallopharmaceuticals. The efficacy of MRI agents is a complex function of chemical, biophysical, and pharmacological properties, which must be married in a package of exquisite safety. This report illustrates the wide range of medicinal chemistry relevant to existing agents that are either approved or in clinical development, as well as concepts, which may result in exciting new pharmaceuticals in the future.
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Cite this article as:
Zhang Zhaoda, Nair A. Shrikumar and McMurry J. Thomas, Gadolinium Meets Medicinal Chemistry: MRI Contrast Agent Development, Current Medicinal Chemistry 2005; 12 (7) . https://dx.doi.org/10.2174/0929867053507379
DOI https://dx.doi.org/10.2174/0929867053507379 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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