Abstract
Dementia is a common and disabling disorder in the elderly. Because of the worldwide aging phenomenon, existing in both developed and developing countries, dementia has a growing public health relevance. This article reviews the prevalence and incidence data for dementia reported in the international literature in the last 10 years. Results from 36 prevalence and 15 incidence studies have been examined. Prevalence is equal to 0.3 to 1.0 per 100 people in individuals aged 60 to 64 years, and increases to 42.3 to 68.3 per 100 people in individuals 95 years and older. The incidence varies from 0.8 to 4.0 per 1000 person years in people aged 60 to 64 years, and increases to 49.8 to 135.7 per 1000 person years when the population was older than 95 years. The international comparison allows the following conclusions: (i) both prevalence and incidence show little geographical variation, as differences between countries seem to reflect methodological rather than real differences [the low prevalence of dementia in Africa needs to be confirmed by incidence data]; (ii) both incidence and prevalence figures increase with age even in the advanced ages; (iii) regarding dementia types, most of the inconsistency in results from different studies is due to vascular dementia rather than to Alzheimer’s disease (AD); (iv) it is still unclear if the reported higher frequency of vascular dementia in Asian populations is due to differential distribution of genetic and/or environmental factors, or due to methodological differences; (v) different dementia types might have different age distributions.
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References
Agüero-Torres H, Fratiglioni L, Guo Z, et al. Prognostic factors in very old demented adults: a seven-year follow-up from a population-based survey in Stockholm. J Am Geriatr Soc 1998 Apr; 46(4): 444–52
Agüero-Torres H, Fratiglioni L, Guo Z, et al. Dementia is the major cause of functional dependence in the elderly: 3-year follow-up data from a population-based study. Am J Public Health 1998 Oct; 88(10): 1452–6
Kalache A. Ageing worldwide. In: Ebrahim S, Kalche A, editors. Epidemiology in old age. London: BMJ, 1996: 22–31
Kinsella K. Demographic aspects. In: Ebrahim S, Kalche A, editors. Epidemiology in old age. London: BMJ, 1996: 32–40
Winker MA, Glass RM. The aging global population: a call for papers. JAMA 1996; 276: 1758
Winker MA. Aging: a global issue. JAMA 1997; 278: 1377
Anonymous. Reducing disability among the elderly in Europe [editorial]. Lancet 1997; 350: 1261
Fratiglioni L. Epidemiology, In: Winblad B, Wimo A, Jonsson B, et al., editors. Health economics of dementia. Chichester: John Wiley & Son Inc., 1998: 13–31
Fratiglioni L, Aguero-Torres H, Winblad B. Impact of dementia in our societies and current possibilities of prevention. Int J Geriatr Psychopharmacol 1998; 1: 179–83
Jorm AF, Korten AE, Henderson AS. The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand 1987 Nov; 76(5): 465–79
Hofman A, Rocca WA, Brayne C, et al. The prevalence of dementia in Europe: a collaborative study of 1980–1990 findings: Eurodem Prevalence Research Group. Int J Epidemiol 1991 Sep; 20(3): 736–48
Rocca WA, Hofman A, Brayne C, et al. Frequency and distribution of Alzheimer’s disease in Europe: a collaborative study of 1980–1990 prevalence findings: the EURODEM-Prevalence Research Group. Ann Neurol 1991 Sep; 30(3): 381–90
Rocca WA, Hofman A, Brayne C, et al. The prevalence of vascular dementia in Europe: facts and fragments from 1980–1990 studies: EURODEM-Prevalence Research Group. Ann Neurol 1991 Dec; 30(6): 817–24
Ritchie K, Kildea D. Is senile dementia ‘age-related’ or ‘ageing-related’? Evidence from meta-analysis of dementia prevalence in the oldest old. Lancet 1995 Oct 7; 346(8980): 91–4
Ritchie K, Kildea D, Robine JM. The relationship between age and the prevalence of senile dementia: a meta-analysis of recent data. Int J Epidemiol 1992 Aug; 21(4): 763–9
Corrada M, Brookmeyer R, Kawas C. Sources of variability in prevalence rates of Alzheimer’s disease. Int J Epidemiol 1995 Oct; 24(5): 1000–5
Jorm AF. Cross-national comparisons of the occurrence of Alzheimer’s and vascular dementias. Eur Arch Psychiatry Clin Neurosci 1991; 240(4–5): 218–22
Rockwood K, Stadnyk K. The prevalence of dementia in the elderly: a review. Can J Psychiatry 1994 Jun; 39(5): 253–7
Jorm AF, Jolley D. The incidence of dementia: a meta-analysis. Neurology 1998 Sep; 51(3): 728–33
Launer LJ, Fratiglioni L, Andersen K, et al. Regional differences in the incidence of dementia in Europe: Eurodem Collaborative analysis. In: Iqbal K, Swaab DF, Winblad B, et al. Alzheimer’s disease and related disorders: etiology, pathogenesis and therapeutics. Chichester: John Wiley & Son Inc., 1999: 9–17
Gao S, Hendrie HC, Hall KS, et al. The relationships between age, sex and the incidence of dementia and Alzheimer’s disease: a meta-analysis. Arch Gen Psychiatry 1998; Sep; 55: 809–15
Hagnell O, Lanke J, Rorsman B, et al. Does the incidence of age psychosis decrease? A prospective, longitudinal study of a complete population investigated during the 25-year period 1947–1972: the Lundby study. Neuropsychobiology 1981; 7(4): 201–11
Sulkava R, Wikstrom J, Aromaa A, et al. Prevalence of severe dementia in Finland. Neurology 1985 Jul; 35(7): 1025–9
Copeland JR, Dewey ME, Wood N, et al. Range of mental illness among the elderly in the community: prevalence in Liverpool using the GMS-AGECAT package. Br J Psychiatry 1987 Jun; 150: 815–23
Heeren TJ, Lagaav AM, Hilmans W, et al. Prevalence of dementia in the ‘oldest old’ in a Dutch population. J Am Geriatr Soc 1991 Aug; 39(8): 755–9
Brayne C, Calloway P. An epidemiological study of dementia in a rural population of elderly women. Br J Psychiatry 1989 Aug; 155: 214–9
Cooper B, Bickel HE. Prevalence and incidence of dementia diseases in the elderly population: results of a population-related longitudinal study in Mannheim [in German]. Nervenarzt 1989 Aug; 60(8): 472–82
Lobo A, Dewey M, Copeland J, et al. The prevalence of dementia among elderly people living in Zaragoza and Liverpool. Psychol Med 1992 Feb; 22(1): 239–43
O’Connor DW, Pollitt PA, Hyde JB, et al. The prevalence of dementia as measured by the Cambridge Mental Disorders of the Elderly Examination. Acta Psychiatr Scand 1989 Feb; 79(2): 190–8
Livingston G, Sax K, Willison J, et al. The Gospel Oak Study stage II: the diagnosis of dementia in the community. Psychol Med 1990 Nov; 20(4): 881–91
Rocca WA, Bonaiuto S, Lippi A, et al. Prevalence of clinically diagnosed Alzheimer’s disease and other dementing disorders: adoor-to-doorsurveyinAppignano,MacerataProvince, Italy. Neurology 1990 Apr; 40(4): 626–31
Fratiglioni L, Grut M, Forsell Y, et al. Prevalence of Alzheimer’s disease and other dementias in an elderly urban population: relationship with age, sex, and education. Neurology 1991 Dec; 41(12): 1886–92
Breteler MM, van den Ouweland FA, Grobbee DE, et al. A community-based study of dementia: the Rotterdam Elderly Study. Neuroepidemiology 1992; 11Suppl. 1: 23–8
Engedal K, Gilje K, Laake K. Prevalence of dementia in a Norwegian sample aged 75 years and over and living at home. Compr Gerontol [A] 1988 Oct; 2(3): 102–6
Juva K, Sulkava R, Erkinjuntti T, et al. Prevalence of dementia in the city of Helsinki. Acta Neurol Scand 1993 Feb; 87(2): 106–10
Skoog I, Nilsson L, Palmertz B, et al. A population-based study of dementia in 85-year-olds. N Engl J Med 1993 Jan 21; 328(3): 153–8
Roelands M, Wostyn P, Dom H, et al. The prevalence of dementia in Belgium: a population-based door-to-door survey in a rural community. Neuroepidemiology 1994; 13(4): 155–61
Wernicke TF, Reischies FM. Prevalence of dementia in old age: clinical diagnoses in subjects aged 95 years and older. Neurology 1994 Feb; 44(2): 250–3
Fichter MM, Meller I, Schroppel H, et al. Dementia and cognitive impairment in the oldest old in the community: prevalence and comorbidity. Br J Psychiatry 1995 May; 166(5): 621–9
Johansson B, Zarit SH. Prevalence and incidence of dementia in the oldest old: a longitudinal study of a population-based sample of 84–90-year-olds in Sweden. Int J Geriatr Psychiatry 1995; 10: 359–66
Prencipe M, Casini AR, Ferretti C, et al. Prevalence of dementia in an elderly rural population: effects of age, sex, and education. J Neurol Neurosurg Psychiatry 1996 Jun; 60(6): 628–33
Andersen K, Lolk A, Nielsen H, et al. Prevalence of very mild to severe dementia in Denmark. Acta Neurol Scand 1997 Aug; 96(2): 82–7
Ferini-Strambi L, Marcone A, Garancini P, et al. Dementing disorders in north Italy: prevalence study in Vescovato, Cremona Province. Eur J Epidemiol 1997 Feb; 13(2): 201–4
Boersma F, Eefsting JA, van den Brink W, et al. Prevalence of dementia in a rural Netherlands population and the influence of DSM-III-R and CAMDEX criteria for the prevalence of mild and more severe forms. J Clin Epidemiol 1998 Mar; 51(3): 189–97
De Ronchi D, Fratiglioni L, Rucci P, et al. The effect of education on dementia occurrence in an Italian population with middle to high socioeconomic status. Neurology 1998 May; 50(5): 1231–8
von Strauss E, Viitanen M, De Ronchi D, et al. Dementia is an ageing related disorder even in the oldest old: evidence from a population aged 90 years and over. Arch Neurol 1999; 56: 587–92
Kokmen E, Beard CM, Offord KP, et al. Prevalence of medically diagnosed dementia in a defined United States population: Rochester, Minnesota, January1, 1975. Neurology 1989 Jun; 39(6): 773–6
Bachman DL, Wolf PA, Linn R, et al. Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study. Neurology 1992 Jan; 42(1): 115–9
Ebly EM, Parhad IM, Hogan DB, et al. Prevalence and types of dementia in the very old: results from the Canadian Study of Health and Aging. Neurology 1994 Sep; 44(9): 1593–600
Hasegawa K, Homma A, Yukimichi I. An epidemiological study of age-related dementia in the community. Int J Geriatr Psychiatry 1986; 1: 45–55
Ueda K, Kawano H, Hasuo Y, et al. Prevalence and etiology of dementia in a Japanese community. Stroke 1992 Jun; 23(6): 798–803
Park J, Ko HJ, Park YN, et al. Dementia among the elderly in a rural Korean community. Br J Psychiatry 1994 Jun; 164(6): 796–801
Shaji S, Promodu K, Abraham T, et al. An epidemiological study of dementia in a rural community in Kerala, India. Br J Psychiatry 1996 Jun; 168(6): 745–9
Chiu HF, Lam LC, Chi I, et al. Prevalence of dementia in Chineseelderly in Hong Kong. Neurology 1998 Apr; 50(4): 1002–9
Graves AB, Larson EB, Edland SD, et al. Prevalence of dementia and its subtypes in the Japanese American population of King County, Washington state: the Kame Project. Am J Epidemiol 1996 Oct 15; 144(8): 760–71
White L, Petrovitch H, Ross GW, et al. Prevalence of dementia in older Japanese-American men in Hawaii: the Honolulu-Asia Aging Study (see comments). MA 1996 Sept 25; 276(12): 955–60
Hendrie HC, Osuntokun BO, Hall KS, et al. Prevalence of Alzheimer’s disease and dementia in two communities: Nigerian Africans and African Americans. Am J Psychiatry 1995 Oct; 152(10): 1485–92
Copeland JR, Davidson IA, Dewey ME, et al. Alzheimer’s disease, other dementias, depression and pseudodementia: prevalence, incidence and three-year outcome in Liverpool. Br J Psychiatry 1992 Aug; 161: 230–9
Bickel H, Cooper B. Incidence and relative risk of dementia in an urban elderly population: findings of a prospective field study. Psychol Med 1994 Feb; 24(1): 179–92
Boothby H, Blizard R, Livingston G, et al. The Gospel Oak Study stage III: the incidence of dementia. Psychol Med 1994 Feb; 24(1): 89–95
Letenneur L, Commenges D, Dartigues JF, et al. Incidence of dementia and Alzheimer’s disease in elderly community residents of south-western France. Int J Epidemiol 1994 Dec; 23(6): 1256–61
Paykel ES, Brayne C, Huppert FA, et al. Incidence of dementia in a population older than 75 years in the United Kingdom. Arch Gen Psychiatry 1994 Apr; 51(4): 325–32
Gussekloo J, Heeren TJ, Izaks GJ, et al. A community based study of the incidence of dementia in subjects aged 85 years and over. J Neurol Neurosurg Psychiatry 1995 Nov; 59(5): 507–10
Aevarsson O, Skoog I. A population-based study on the incidence of dementia disorders between 85 and 88 years of age. J Am Geriatr Soc 1996 Dec; 44(12): 1455–60
Fichter MM, Schroppel H, Meller I. Incidence of dementia in a Munich community sample of the oldest old. Eur Arch Psychiatry Clin Neurosci 1996; 246(6): 320–8
Brayne C, Best N, Muir M, et al. Five-year incidence and prediction of dementia and cognitive decline in a population sample of women aged 70–79 at baseline. Int J Geriatr Psychiatry 1997 Nov; 12(11): 1107–18
Fratiglioni L, Viitanen M, von Strauss E, et al. Very old women at highest risk of dementia and Alzheimer’s disease: incidence data from the Kungsholmen Project, Stockholm. Neurology 1997 Jan; 48(1): 132–8
Ott A, Breteler MM, van Harskamp F, et al. Incidence and risk of dementia: the Rotterdam Study. Am J Epidemiol 1998 Mar 15; 147(6): 574–80
Bachman DL, Wolf PA, Linn RT, et al. Risk Incidence of dementia and probable Alzheimer’s disease in a general population: the Framingham Study. Neurology 1993 Mar; 43 (3 Pt 1): 515–9
Rocca WA, Cha RH, Waring SC, et al. Incidence of dementia and Alzheimer’s disease: a reanalysis of data from Rochester, Minnesota, 1975–1984. Am J Epidemiol 1998 Jul 1; 148(1): 51–62
Li G, Shen YC, Chen CH, et al. A three-year follow-up study of age-related dementia in an urban area of Beijing. Acta Psychiatr Scand 1991 Feb; 83(2): 99–104
Liu CK, Lai CL, Tai CT, et al. Incidence and subtypes of dementia in southern Taiwan: impact of socio-demographic factors. Neurology 1998 Jun; 50(6): 1572–9
Corder EH, Lannfelt L, Bogdanovic N, et al. The role of APOE polymorphisms in late-onset dementias. Cell Mol Life Sci 1998 Sep; 54(9): 928–34
Kalaria RN, Ogeng’o JA, Patel NB, et al. Evaluation of risk factors for Alzheimer’s disease in elderly east Africans. Brain Res Bull 1997; 44(5): 573–7
Fratiglioni L. Classifications and diagnostics. In: Winblad B, Wimo A, Jonsson B, et al., editors. Health economics of dementia. Chichester: John Wiley & Son Inc., 1998: 3–11
Hebert R, Brayne C. Epidemiology of vascular dementia. Neuroepidemiology 1995; 14(5): 240–57
van Duijn CM. Epidemiology of the dementias: recent developments and new approaches. J Neurol Neurosurg Psychiatry 1996 May; 60(5): 478–88
Perkins P, Annegers JF, Doody RS, et al. Incidence and prevalence of dementia in a multiethnic cohort of municipal retirees. Neurology 1997 Jul; 49(1): 44–50
Pasquier F, Leys D. Why are stroke patients prone to develop dementia? J Neurol 1997 Mar; 244(3): 135–42
Graham C, Howard R, Ha Y. Dementia and ethnicity. Int Psychogeriatr 1998 Jun; 10(2): 183–91
Prince M. The need for research on dementia in developing countries. Trop Med Int Health 1997 Oct; 2(10): 993–1000
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Fratiglioni, L., De Ronchi, D. & Agüero-Torres, H. Worldwide Prevalence and Incidence of Dementia. Drugs Aging 15, 365–375 (1999). https://doi.org/10.2165/00002512-199915050-00004
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DOI: https://doi.org/10.2165/00002512-199915050-00004