Library Subscription: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90

Volume 35, Issue 2, 2016, pp. 185-192
DOI: 10.1615/JEnvironPatholToxicolOncol.2016016903
Get accessGet access

ABSTRACT

The translation of photodynamic therapy (PDT) to the clinical setting has primarily been limited to easily accessible and/or superficial diseases, for which traditional light delivery can be performed noninvasively. Cerenkov radiation, as generated from medically relevant radionuclides, has been suggested as a means to deliver light to deeper tissues noninvasively to overcome this depth limitation. This article investigates the utility of Cerenkov radiation, as generated from the radionuclide yttrium-90, for activating the PDT process using clinically approved aminolevulinic acid at 1.0 mm and also the more efficient porphyrin-based photosensitizer mesotetraphenylporphine with two sulfonate groups on adjacent phenyl rings (TPPS2a) at 1.2 µm. Experiments were conducted with monolayer cultured glioma and breast tumor cell lines. Although aminolevulinic acid proved to be ineffective for generating a therapeutic effect at all but the highest activity levels, TPPS2a produced at least a 20% therapeutic effect at activities ranging from 6 to 60 µCi/well for the C6 glioma cell line. Importantly, these results demonstrate for the first time, to our knowledge, that Cerenkov radiation generated from a radionuclide can be used to activate PDT using clinically relevant photosensitizers. These results therefore provide evidence that it may be possible to generate a phototherapeutic effect in vivo using Cerenkov radiation and clinically relevant photosensitizers.

CITED BY
  1. Kharroubi Lakouas Dris, Huglo Damien, Mordon Serge, Vermandel Maximilien, Nuclear medicine for photodynamic therapy in cancer: Planning, monitoring and nuclear PDT, Photodiagnosis and Photodynamic Therapy, 18, 2017. Crossref

  2. Kotagiri Nalinikanth, Laforest Richard, Achilefu Samuel, Reply to ‘Is Cherenkov luminescence bright enough for photodynamic therapy?’, Nature Nanotechnology, 13, 5, 2018. Crossref

  3. Pratt Edwin C., Shaffer Travis M., Zhang Qize, Drain Charles Michael, Grimm Jan, Nanoparticles as multimodal photon transducers of ionizing radiation, Nature Nanotechnology, 13, 5, 2018. Crossref

  4. Tamura Ryo, Pratt Edwin C., Grimm Jan, Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging, Seminars in Nuclear Medicine, 48, 4, 2018. Crossref

  5. Kotagiri Nalinikanth, Cooper Matthew L., Rettig Michael, Egbulefu Christopher, Prior Julie, Cui Grace, Karmakar Partha, Zhou Mingzhou, Yang Xiaoxia, Sudlow Gail, Marsala Lynne, Chanswangphuwana Chantiya, Lu Lan, Habimana-Griffin LeMoyne, Shokeen Monica, Xu Xinming, Weilbaecher Katherine, Tomasson Michael, Lanza Gregory, DiPersio John F., Achilefu Samuel, Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer, Nature Communications, 9, 1, 2018. Crossref

  6. Shrock Zachary, Yoon Suk W., Gunasingha Rathnayaka, Oldham Mark, Adamson Justus, Technical Note: On maximizing Cherenkov emissions from medical linear accelerators, Medical Physics, 45, 7, 2018. Crossref

  7. Niu Gang, Chen Xiaoyuan, When radionuclides meet nanoparticles, Nature Nanotechnology, 13, 5, 2018. Crossref

  8. Ferreira Carolina A., Ni Dalong, Rosenkrans Zachary T., Cai Weibo, Radionuclide‐Activated Nanomaterials and Their Biomedical Applications, Angewandte Chemie International Edition, 58, 38, 2019. Crossref

  9. Ferreira Carolina A., Ni Dalong, Rosenkrans Zachary T., Cai Weibo, Radionuklidaktivierte Nanomaterialien und ihre biomedizinische Anwendung, Angewandte Chemie, 131, 38, 2019. Crossref

  10. Characterization of Surface Contaminants and Features, in Developments in Surface Contamination and Cleaning, Volume 12, 2019. Crossref

  11. References, in Developments in Surface Contamination and Cleaning, Volume 12, 2019. Crossref

  12. Klein Justin S, Sun Conroy, Pratx Guillem, Radioluminescence in biomedicine: physics, applications, and models, Physics in Medicine & Biology, 64, 4, 2019. Crossref

  13. Huang Yu, Qiu Feng, Chen Rongjun, Yan Deyue, Zhu Xinyuan, Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy, Journal of Materials Chemistry B, 8, 17, 2020. Crossref

  14. Stater Evan P., Skubal Magdalena, Tamura Ryo, Grimm Jan, The Present and Future of Optical Imaging Technologies in the Clinic: Diagnosis and Therapy, in Fluorescent Imaging in Medicinal Chemistry, 34, 2019. Crossref

  15. Panetta Joseph V, Cvetkovic Dusica, Chen Xiaoming, Chen Lili, Ma C-M Charlie, Radiodynamic therapy using 15-MV radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo, Physics in Medicine & Biology, 65, 16, 2020. Crossref

  16. Daouk Joël, Dhaini Batoul, Petit Jérôme, Frochot Céline, Barberi-Heyob Muriel, Schohn Hervé, Can Cerenkov Light Really Induce an Effective Photodynamic Therapy?, Radiation, 1, 1, 2020. Crossref

  17. Quintos-Meneses Hilda Angeline, Aranda-Lara Liliana, Morales-Ávila Enrique, Torres-García Eugenio, Camacho-López Miguel Ángel, Sánchez-Holguín Mariana, Luna-Gutiérrez Myrna A., Ramírez-Durán Ninfa, Isaac-Olivé Keila, In vitro irradiation of doxorubicin with 18F-FDG Cerenkov radiation and its potential application as a theragnostic system., Journal of Photochemistry and Photobiology B: Biology, 210, 2020. Crossref

  18. Boschi Federico, Spinelli Antonello Enrico, Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy, Nanomaterials, 10, 9, 2020. Crossref

  19. Drzewiecka-Matuszek Agnieszka, Rutkowska-Zbik Dorota, Application of TD-DFT Theory to Studying Porphyrinoid-Based Photosensitizers for Photodynamic Therapy: A Review, Molecules, 26, 23, 2021. Crossref

  20. Spinelli Antonello E., Boschi Federico, Photodynamic Therapy Using Cerenkov and Radioluminescence Light, Frontiers in Physics, 9, 2021. Crossref

  21. Dias Cristina J., Helguero Luisa, Faustino Maria Amparo F., Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer, Molecules, 26, 24, 2021. Crossref

  22. Algorri José Francisco, Ochoa Mario, Roldán-Varona Pablo, Rodríguez-Cobo Luís, López-Higuera José Miguel, Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review, Cancers, 13, 14, 2021. Crossref

  23. Lioret Vivian, Bellaye Pierre-Simon, Arnould Christine, Collin Bertrand, Decréau Richard A., Dual Cherenkov Radiation-Induced Near-Infrared Luminescence Imaging and Photodynamic Therapy toward Tumor Resection, Journal of Medicinal Chemistry, 63, 17, 2020. Crossref

  24. Lin Li, Song Xuejiao, Dong Xiaocheng, Li Buhong, Nano-photosensitizers for enhanced photodynamic therapy, Photodiagnosis and Photodynamic Therapy, 36, 2021. Crossref

  25. Shaffer Travis M., Drain Charles Michael, Grimm Jan, Optical Imaging of Ionizing Radiation from Clinical Sources, Journal of Nuclear Medicine, 57, 11, 2016. Crossref

  26. Arroyo Alejandro D., Guzman Andrea E., Kachur Alexander V., Popov Anatoliy V., Delikatny E. James, Development of 18F-Labeled Resazurin Derivatives for the Detection of Tumor Metabolic Activity Using Cerenkov Imaging, Frontiers in Physics, 9, 2021. Crossref

  27. Tamura Ryo, Balabanova Alla, Frakes Samuel A., Bargmann Austin, Grimm Jan, Koch Tad H., Yin Hang, Photoactivatable Prodrug of Doxazolidine Targeting Exosomes, Journal of Medicinal Chemistry, 62, 4, 2019. Crossref

  28. Jiménez-Mancilla Nallely P., Aranda-Lara Liliana, Morales-Ávila Enrique, Camacho-López Miguel A., Ocampo-García Blanca E., Torres-García Eugenio, Estrada-Guadarrama José A., Santos-Cuevas Clara L., Isaac-Olivé Keila, Electron transfer reactions in rhodamine: Potential use in photodynamic therapy, Journal of Photochemistry and Photobiology A: Chemistry, 409, 2021. Crossref

  29. Cline Benjamin, Delahunty Ian, Xie Jin, Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy, WIREs Nanomedicine and Nanobiotechnology, 11, 2, 2019. Crossref

  30. Wang Xianliang, Li Lintao, Li Jie, Wang Pei, Lang Jinyi, Yang Yuanjie, Cherenkov Luminescence in Tumor Diagnosis and Treatment: A Review, Photonics, 9, 6, 2022. Crossref

  31. Torres-García Eugenio, Torres-Velazquez Hansel, Díaz-Sánchez Luis E., Aranda-Lara Liliana, Isaac-Olivé Keila, Determination of experimental Cherenkov spectrum (200–1050 nm) of 18F and its implications on optical dosimetry: murine model, Radiation Effects and Defects in Solids, 2022. Crossref

  32. Ávila-Sánchez Marcela A., Isaac-Olivé Keila, Aranda-Lara Liliana, Morales-Ávila Enrique, Plata-Becerril Adriana, Jiménez-Mancilla Nallely P., Ocampo-García Blanca, Estrada José A., Santos-Cuevas Clara L., Torres-García Eugenio, Camacho-López Miguel A., Targeted photodynamic therapy using reconstituted high-density lipoproteins as rhodamine transporters, Photodiagnosis and Photodynamic Therapy, 37, 2022. Crossref

  33. Gallaga-González Uriel, Morales-Avila Enrique, Torres-García Eugenio, Estrada José A., Díaz-Sánchez Luis Enrique, Izquierdo German, Aranda-Lara Liliana, Isaac-Olivé Keila, Photoactivation of Chemotherapeutic Agents with Cerenkov Radiation for Chemo-Photodynamic Therapy, ACS Omega, 7, 27, 2022. Crossref

  34. Malone Christopher D., Egbulefu Christopher, Zheleznyak Alexander, Polina Jahnavi, Karmakar Partha, Black Kvar, Shokeen Monica, Achilefu Samuel, Activation of nano-photosensitizers by Y-90 microspheres to enhance oxidative stress and cell death in hepatocellular carcinoma, Scientific Reports, 12, 1, 2022. Crossref

  35. Jiang Fangchao, Chong Harrison, Xie Jin, Nanoparticles for X-ray or Cherenkov radiation-induced photodynamic therapy, in Reference Module in Materials Science and Materials Engineering, 2022. Crossref

  36. Moghassemi Saeid, Dadashzadeh Arezoo, de Azevedo Ricardo Bentes, Amorim Christiani A., Secure transplantation by tissue purging using photodynamic therapy to eradicate malignant cells, Journal of Photochemistry and Photobiology B: Biology, 234, 2022. Crossref

  37. Bianfei Shao, Fang Liu, Zhongzheng Xiang, Yuanyuan Zeng, Tian Yang, Tao He, Jiachun Ma, Xiran Wang, Siting Yu, Lei Liu, Application of Cherenkov radiation in tumor imaging and treatment, Future Oncology, 18, 27, 2022. Crossref

  38. Rodrigues José A., Correia José H., Enhanced Photodynamic Therapy: A Review of Combined Energy Sources, Cells, 11, 24, 2022. Crossref

1561 Article views 70 Article downloads Metrics
1561 VIEWS 70 DOWNLOADS 38 Crossref CITATIONS Google
Scholar
CITATIONS

Articles with similar content:

Spectroscopic Measurements of Photoinduced Processes in Human Skin after Topical Application of the Hexyl Ester of 5-Aminolevulinic Acid Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Lu Zhao, Knut Stamnes, Jakob J. Stamnes, Asta Juzeniene, Kristian Pagh Nielsen, Petras Juzenas, Vladimir Lani, Li-Wei Ma, Johan Moan
Gene Expression Profile in Murine 3T3 Fibroblasts Photosensitized by a Tetracationic Porphyrin Onco Therapeutics, Vol.2, 2011, issue 3
Laura Guidolin, Marina Soncin, Francesco Boldrin, Monica Camerin, Giulio Jori, Gianfranco Santovito, Paola Irato, Ester Piccinni
Updated Results of a Phase I Trial of Motexafin Lutetium-Mediated Interstitial Photodynamic Therapy in Patients with Locally Recurrent Prostate Cancer Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Eli Glatstein, Andreea Dimofte, Kosmas Verigos, Stephen M. Hahn, Zelig A. Tochner, Jarod Finlay, Richard Whittington, Debbie Smith, Theresa M. Busch, Rosemarie Mick, Diana C. Hsiung Stripp, S. Bruce Malkowicz, Timothy C. Zhu
Thermal Effect of Laser on Silver Nanoparticles Synthesized by the Cold Plasma Method on Cancer Cells Plasma Medicine, Vol.13, 2023, issue 1
Ban. H Adil, Maryam Ali Raheem
Repetitive Photodynamic Therapy of Malignant Brain Tumors Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Signe Spetalen, Henry Hirschberg, Bruce Tromberg, Even Angell-Petersen, Dag R. Sorensen, Steen J. Madsen, Qian Peng, Chung-Ho Sun
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain