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ISSN Print: 0731-8898
ISSN Online: 2162-6537
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Activating Photodynamic Therapy in vitro with Cerenkov Radiation Generated from Yttrium-90
ABSTRACT
The translation of photodynamic therapy (PDT) to the clinical setting has primarily been limited to easily accessible and/or superficial diseases, for which traditional light delivery can be performed noninvasively. Cerenkov radiation, as generated from medically relevant radionuclides, has been suggested as a means to deliver light to deeper tissues noninvasively to overcome this depth limitation. This article investigates the utility of Cerenkov radiation, as generated from the radionuclide yttrium-90, for activating the PDT process using clinically approved aminolevulinic acid at 1.0 mm and also the more efficient porphyrin-based photosensitizer mesotetraphenylporphine with two sulfonate groups on adjacent phenyl rings (TPPS2a) at 1.2 µm. Experiments were conducted with monolayer cultured glioma and breast tumor cell lines. Although aminolevulinic acid proved to be ineffective for generating a therapeutic effect at all but the highest activity levels, TPPS2a produced at least a 20% therapeutic effect at activities ranging from 6 to 60 µCi/well for the C6 glioma cell line. Importantly, these results demonstrate for the first time, to our knowledge, that Cerenkov radiation generated from a radionuclide can be used to activate PDT using clinically relevant photosensitizers. These results therefore provide evidence that it may be possible to generate a phototherapeutic effect in vivo using Cerenkov radiation and clinically relevant photosensitizers.
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Kharroubi Lakouas Dris, Huglo Damien, Mordon Serge, Vermandel Maximilien, Nuclear medicine for photodynamic therapy in cancer: Planning, monitoring and nuclear PDT, Photodiagnosis and Photodynamic Therapy, 18, 2017. Crossref
-
Kotagiri Nalinikanth, Laforest Richard, Achilefu Samuel, Reply to ‘Is Cherenkov luminescence bright enough for photodynamic therapy?’, Nature Nanotechnology, 13, 5, 2018. Crossref
-
Pratt Edwin C., Shaffer Travis M., Zhang Qize, Drain Charles Michael, Grimm Jan, Nanoparticles as multimodal photon transducers of ionizing radiation, Nature Nanotechnology, 13, 5, 2018. Crossref
-
Tamura Ryo, Pratt Edwin C., Grimm Jan, Innovations in Nuclear Imaging Instrumentation: Cerenkov Imaging, Seminars in Nuclear Medicine, 48, 4, 2018. Crossref
-
Kotagiri Nalinikanth, Cooper Matthew L., Rettig Michael, Egbulefu Christopher, Prior Julie, Cui Grace, Karmakar Partha, Zhou Mingzhou, Yang Xiaoxia, Sudlow Gail, Marsala Lynne, Chanswangphuwana Chantiya, Lu Lan, Habimana-Griffin LeMoyne, Shokeen Monica, Xu Xinming, Weilbaecher Katherine, Tomasson Michael, Lanza Gregory, DiPersio John F., Achilefu Samuel, Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer, Nature Communications, 9, 1, 2018. Crossref
-
Shrock Zachary, Yoon Suk W., Gunasingha Rathnayaka, Oldham Mark, Adamson Justus, Technical Note: On maximizing Cherenkov emissions from medical linear accelerators, Medical Physics, 45, 7, 2018. Crossref
-
Niu Gang, Chen Xiaoyuan, When radionuclides meet nanoparticles, Nature Nanotechnology, 13, 5, 2018. Crossref
-
Ferreira Carolina A., Ni Dalong, Rosenkrans Zachary T., Cai Weibo, Radionuclide‐Activated Nanomaterials and Their Biomedical Applications, Angewandte Chemie International Edition, 58, 38, 2019. Crossref
-
Ferreira Carolina A., Ni Dalong, Rosenkrans Zachary T., Cai Weibo, Radionuklidaktivierte Nanomaterialien und ihre biomedizinische Anwendung, Angewandte Chemie, 131, 38, 2019. Crossref
-
Characterization of Surface Contaminants and Features, in Developments in Surface Contamination and Cleaning, Volume 12, 2019. Crossref
-
References, in Developments in Surface Contamination and Cleaning, Volume 12, 2019. Crossref
-
Klein Justin S, Sun Conroy, Pratx Guillem, Radioluminescence in biomedicine: physics, applications, and models, Physics in Medicine & Biology, 64, 4, 2019. Crossref
-
Huang Yu, Qiu Feng, Chen Rongjun, Yan Deyue, Zhu Xinyuan, Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy, Journal of Materials Chemistry B, 8, 17, 2020. Crossref
-
Stater Evan P., Skubal Magdalena, Tamura Ryo, Grimm Jan, The Present and Future of Optical Imaging Technologies in the Clinic: Diagnosis and Therapy, in Fluorescent Imaging in Medicinal Chemistry, 34, 2019. Crossref
-
Panetta Joseph V, Cvetkovic Dusica, Chen Xiaoming, Chen Lili, Ma C-M Charlie, Radiodynamic therapy using 15-MV radiation combined with 5-aminolevulinic acid and carbamide peroxide for prostate cancer in vivo, Physics in Medicine & Biology, 65, 16, 2020. Crossref
-
Daouk Joël, Dhaini Batoul, Petit Jérôme, Frochot Céline, Barberi-Heyob Muriel, Schohn Hervé, Can Cerenkov Light Really Induce an Effective Photodynamic Therapy?, Radiation, 1, 1, 2020. Crossref
-
Quintos-Meneses Hilda Angeline, Aranda-Lara Liliana, Morales-Ávila Enrique, Torres-García Eugenio, Camacho-López Miguel Ángel, Sánchez-Holguín Mariana, Luna-Gutiérrez Myrna A., Ramírez-Durán Ninfa, Isaac-Olivé Keila, In vitro irradiation of doxorubicin with 18F-FDG Cerenkov radiation and its potential application as a theragnostic system., Journal of Photochemistry and Photobiology B: Biology, 210, 2020. Crossref
-
Boschi Federico, Spinelli Antonello Enrico, Nanoparticles for Cerenkov and Radioluminescent Light Enhancement for Imaging and Radiotherapy, Nanomaterials, 10, 9, 2020. Crossref
-
Drzewiecka-Matuszek Agnieszka, Rutkowska-Zbik Dorota, Application of TD-DFT Theory to Studying Porphyrinoid-Based Photosensitizers for Photodynamic Therapy: A Review, Molecules, 26, 23, 2021. Crossref
-
Spinelli Antonello E., Boschi Federico, Photodynamic Therapy Using Cerenkov and Radioluminescence Light, Frontiers in Physics, 9, 2021. Crossref
-
Dias Cristina J., Helguero Luisa, Faustino Maria Amparo F., Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer, Molecules, 26, 24, 2021. Crossref
-
Algorri José Francisco, Ochoa Mario, Roldán-Varona Pablo, Rodríguez-Cobo Luís, López-Higuera José Miguel, Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review, Cancers, 13, 14, 2021. Crossref
-
Lioret Vivian, Bellaye Pierre-Simon, Arnould Christine, Collin Bertrand, Decréau Richard A., Dual Cherenkov Radiation-Induced Near-Infrared Luminescence Imaging and Photodynamic Therapy toward Tumor Resection, Journal of Medicinal Chemistry, 63, 17, 2020. Crossref
-
Lin Li, Song Xuejiao, Dong Xiaocheng, Li Buhong, Nano-photosensitizers for enhanced photodynamic therapy, Photodiagnosis and Photodynamic Therapy, 36, 2021. Crossref
-
Shaffer Travis M., Drain Charles Michael, Grimm Jan, Optical Imaging of Ionizing Radiation from Clinical Sources, Journal of Nuclear Medicine, 57, 11, 2016. Crossref
-
Arroyo Alejandro D., Guzman Andrea E., Kachur Alexander V., Popov Anatoliy V., Delikatny E. James, Development of 18F-Labeled Resazurin Derivatives for the Detection of Tumor Metabolic Activity Using Cerenkov Imaging, Frontiers in Physics, 9, 2021. Crossref
-
Tamura Ryo, Balabanova Alla, Frakes Samuel A., Bargmann Austin, Grimm Jan, Koch Tad H., Yin Hang, Photoactivatable Prodrug of Doxazolidine Targeting Exosomes, Journal of Medicinal Chemistry, 62, 4, 2019. Crossref
-
Jiménez-Mancilla Nallely P., Aranda-Lara Liliana, Morales-Ávila Enrique, Camacho-López Miguel A., Ocampo-García Blanca E., Torres-García Eugenio, Estrada-Guadarrama José A., Santos-Cuevas Clara L., Isaac-Olivé Keila, Electron transfer reactions in rhodamine: Potential use in photodynamic therapy, Journal of Photochemistry and Photobiology A: Chemistry, 409, 2021. Crossref
-
Cline Benjamin, Delahunty Ian, Xie Jin, Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy, WIREs Nanomedicine and Nanobiotechnology, 11, 2, 2019. Crossref
-
Wang Xianliang, Li Lintao, Li Jie, Wang Pei, Lang Jinyi, Yang Yuanjie, Cherenkov Luminescence in Tumor Diagnosis and Treatment: A Review, Photonics, 9, 6, 2022. Crossref
-
Torres-García Eugenio, Torres-Velazquez Hansel, Díaz-Sánchez Luis E., Aranda-Lara Liliana, Isaac-Olivé Keila, Determination of experimental Cherenkov spectrum (200–1050 nm) of 18F and its implications on optical dosimetry: murine model, Radiation Effects and Defects in Solids, 2022. Crossref
-
Ávila-Sánchez Marcela A., Isaac-Olivé Keila, Aranda-Lara Liliana, Morales-Ávila Enrique, Plata-Becerril Adriana, Jiménez-Mancilla Nallely P., Ocampo-García Blanca, Estrada José A., Santos-Cuevas Clara L., Torres-García Eugenio, Camacho-López Miguel A., Targeted photodynamic therapy using reconstituted high-density lipoproteins as rhodamine transporters, Photodiagnosis and Photodynamic Therapy, 37, 2022. Crossref
-
Gallaga-González Uriel, Morales-Avila Enrique, Torres-García Eugenio, Estrada José A., Díaz-Sánchez Luis Enrique, Izquierdo German, Aranda-Lara Liliana, Isaac-Olivé Keila, Photoactivation of Chemotherapeutic Agents with Cerenkov Radiation for Chemo-Photodynamic Therapy, ACS Omega, 7, 27, 2022. Crossref
-
Malone Christopher D., Egbulefu Christopher, Zheleznyak Alexander, Polina Jahnavi, Karmakar Partha, Black Kvar, Shokeen Monica, Achilefu Samuel, Activation of nano-photosensitizers by Y-90 microspheres to enhance oxidative stress and cell death in hepatocellular carcinoma, Scientific Reports, 12, 1, 2022. Crossref
-
Jiang Fangchao, Chong Harrison, Xie Jin, Nanoparticles for X-ray or Cherenkov radiation-induced photodynamic therapy, in Reference Module in Materials Science and Materials Engineering, 2022. Crossref
-
Moghassemi Saeid, Dadashzadeh Arezoo, de Azevedo Ricardo Bentes, Amorim Christiani A., Secure transplantation by tissue purging using photodynamic therapy to eradicate malignant cells, Journal of Photochemistry and Photobiology B: Biology, 234, 2022. Crossref
-
Bianfei Shao, Fang Liu, Zhongzheng Xiang, Yuanyuan Zeng, Tian Yang, Tao He, Jiachun Ma, Xiran Wang, Siting Yu, Lei Liu, Application of Cherenkov radiation in tumor imaging and treatment, Future Oncology, 18, 27, 2022. Crossref
-
Rodrigues José A., Correia José H., Enhanced Photodynamic Therapy: A Review of Combined Energy Sources, Cells, 11, 24, 2022. Crossref