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Licensed Unlicensed Requires Authentication Published by De Gruyter (O) September 25, 2009

Semi-remote production of Br-76 and preparation of high specific activity radiobrominated pharmaceuticals for PET studies

  • Lawrence P. Szajek , C.-H. K. Kao , D. O. Kiesewetter , M. B. Sassaman , L. Lang , P. Plascjak and W. C. Eckelman
From the journal Radiochimica Acta

Abstract

The PET radionuclide 76Br (t1/2=16.2 h) can be easily produced utilizing the nuclear reaction As(3He,2n)76Br. We use high-purity arsenic targets and isolate radioactive bromide by chromic acid oxidation followed by simple distillation of [76Br] hydrogen bromide using a semi-remote apparatus. Use of reagents with little or no carrier bromine yields high specific activity radiobrominated pharmaceuticals prepared from the distilled [76Br] hydrogen bromide.

Published Online: 2009-9-25
Published in Print: 2004-4-1

© 2004 Oldenbourg Wissenschaftsverlag GmbH

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