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Licensed Unlicensed Requires Authentication Published by De Gruyter (O) September 25, 2009

223Ra for endoradiotherapeutic applications prepared from an immobilized 227Ac/227Th source

  • Gjermund Henriksen , P. Hoff , J. Alstad and R. H. Larsen
From the journal Radiochimica Acta

A method is described for the production of 223Ra (t1/2=11.4 d) in a quality useful for endoradiotherapeutic applications. The method is based on a long term operating generator with a source of 227Ac (t1/2=21.7 years), from which 223Ra is eluted. The 227Ac was isolated from a 231Pa source using the f-element selective extraction chromatographic material TRU-resin. The purified 227Ac/227Th source was subsequently applied to another extraction chromatographic resin, containing the extractant P,P-di(2-ethylhexyl)methanediphosphonic acid on silica (Dipex-2) and used as a generator for 223Ra. From the generator column, the yield of 223Ra was about 60 kBq per 100 kBq of 227Ac with a highly effective separation of 223Ra from the precursors. In production runs, the activity of 227Ac was found to be 6×10-6 relative to the eluted activity of 223Ra. By using a second column of Dipex-2 for additional purification, the activity of Ac was reduced to below 7×10-8 relative to 223Ra with nearly quantitative recovery of 223Ra. The described procedure resulted in a high purity 223Ra preparation, potentially useful in, e.g., targeted radiotherapy of tumors.

Published Online: 2009-9-25
Published in Print: 2001-10-1

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