Chest
Clinical InvestigationsCARDIOLOGYDobutamine Gated Blood Pool Scintigraphy Predicts the Improvement of Cardiac Sympathetic Nerve Activity, Cardiac Function, and Symptoms After Treatment in Patients With Dilated Cardiomyopathy
Section snippets
Study Population
Twenty-two patients, 12 men and 10 women (mean ± SD age, 56 ± 12 years; range, 35 to 78 years), with DCM were included in the study. A detailed history and physical were obtained from all of the patients. Chest radiography, standard ECG, echocardiography, 201Tl and 123I-MIBG scintigraphy, and cardiac catheterization, including coronary angiography and left ventriculography, were performed in all of the patients. Patients with acute or chronic myocarditis, significant coronary artery stenosis,
Results
There were no significant differences in the hemodynamic characteristics of the two groups. Before treatment, TDS, H/M ratio, LVEF, and LVDd were similar in both groups. ΔLVEF is shown in Figure 5. ΔLVEF in group A was 21 ± 8%, which was significantly higher than the ΔLVEF in group B (9 ± 3%, p < 0.001). The correlation was recognized between LVEF measured by echocardiography and LVEF measured by scintigraphy at rest (Fig 6). Using a critical value of 15% for the ΔLVEF to predict an improvement
Discussion
Idiopathic DCM, which is characterized by dilated ventricles and decreased systolic function, is generally regarded as having a poor prognosis. In early reports,2223 the survival rate for patients with DCM was 70 to 75% at 1 year and 50% at 5 years. However, in later reports,2425 the prognosis has improved, with a 5-year survival rate of 60 to 80%. Earlier detection of the disease, as well as the introduction of treatments with β-blockers, may be related to this improvement in prognosis.2345678
Conclusion
DOB-GBP can be used to predict improvement in cardiac sympathetic nerve activity, cardiac function, and symptoms after treatment with β-blocker in patients with DCM.
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2005, American Heart JournalCitation Excerpt :Patients with left ventriculographic LVEF <40% at this time were entered into this study. The method used for 123I-MIBG imaging has been described previously.11,17-23 The 123I-MIBG was obtained from a commercial source (Daiichi Radioisotope Laboratories, Tokyo, Japan).
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2005, Journal of the American College of CardiologyCitation Excerpt :Examinations were conducted before and after six months of treatment. The method of 123I-MIBG imaging has been described previously (10–14). The tracer was obtained from Daiichi Radioisotope Laboratories (Tokyo, Japan), and a dose of 111 MBq was injected intravenously while the patient was in a supine position.