Chest
Clinical Investigations: CancerDynamic Positron Emission Tomography With F-18 Fluorodeoxyglucose Imaging in Differentiation of Benign From Malignant Lung/Mediastinal Lesions
Section snippets
MATERIALS AND METHODS
We studied 19 consecutive patients with an age range of 32 to 78 years referred for F-18 FDG PET studies for suspected malignant lesions in the lungs or in the mediastinum. These successive patients were studied as part of ongoing clinical studies at West Virginia University PET Center. All patients provided an informed consent for the PET studies. All patients fasted for at least 4 h prior to FDG injection. Serum glucose levels ranged from 80 to 160 mg/dL. These patients also had complete
RESULTS
The histologic specimens were obtained by needle biopsy (n = 10), thoracotomy (n = 8), or bronchoscopy (n = 1). Lesions ranged in size from 1 to 3.5 cm.
DISCUSSION
The high metabolism and increased rate of glucose consumption of cancer is associated with increased level of glycolytic enzymes and overexpression of glucose transporters as compared with the surrounding normal tissues.4, 10 It is well accepted that increased rates of transport and phosphorylation of the glucose analog and decreased rate of dephosphorylation of the phosphorylated sugars are important factors in the cellular mechanisms for tumor hypermetabolism.5, 6 Significant correlation has
REFERENCES (18)
- et al.
Assessment of primary and metastatic ovarian cancer by positron emission tomography (PET) using 2-(18F)deoxyglucose (2[18F]FDG)
Gynecol Oncol
(1993) - et al.
Clinical applications of positron emission tomography in cancer
Ca Cancer J Clin
(1993) - et al.
Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-glucose
Radiology
(1992) - et al.
Semiquantitative and visual analysis of FDG-PET images in pulmonary abnormalities
J Nucl Med
(1994) - et al.
Physicochemical properties and isoenzyme composition of hexokinase from normal and malignant human tissues
J Natl Cancer Inst
(1978) The metabolism of tumors
(1931)Enzymology of cancer cells (first of two parts)
N Engl J Med
(1937)- et al.
Normal variability in the mediastinal FDG activity on FDG PET studies of lung tumors
Radiology
(1994) - et al.
Graphical evaluation of blood-to-brain transfer constant from multipletime uptake data
J Cereb Blood Flow Metab
(1981)
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Presented as a scientific paper at Radiologic Society of North America meeting, December 1996