Chest
Original ResearchCOPDReduced Intrathoracic Blood Volume and Left and Right Ventricular Dimensions in Patients With Severe Emphysema: An MRI Study
Section snippets
Materials and Methods
The local Ethics Committee of the Medical Faculty of Göteborg University approved the study protocol, written informed consent was obtained from all subjects, and the study complied with the recommendations found in the Declaration of Helsinki.6 Criteria for inclusion in the emphysema group (n = 13) were a history of lung emphysema based on physical examination, chest radiography, and pulmonary function test results: FEV1 from 15 to 30% of predicted value; total lung capacity > 120% of
Results
There were no differences between the groups regarding age, height, or weight (Table 1). The emphysema patients had the typical functional features of severe pulmonary emphysema: severe obstruction to expiratory airflow and considerable hyperinflation (Table 1).
Discussion
The main findings of this study were that cardiac performance was compromised in patients with severe pulmonary emphysema, as demonstrated by a lower SVI, when compared to control subjects matched for gender, age, and BSA. Although we have not proven a cause-effect relationship, the close relationship between ITBVI and LVEDVI and between LVEDVI and SVI (Fig 5, 6) strongly suggest that a low preload, caused by intrathoracic hypovolemia, contributes to the impaired LV performance seen in patients
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Cited by (0)
This study was supported by the Swedish Medical Research Council, No. 13156 and the Medical Faculty of Gothenburg.
No financial or other potential conflicts of interest exist for any of the authors.