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The Impact of Perineural Invasion and/or Lymphovascular Invasion on the Survival of Early-Stage Oral Squamous Cell Carcinoma Patients

  • Head and Neck Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

For early-stage oral squamous cell carcinoma (OSCC) patients, the impact of perineural invasion (PNI) and lymphovascular invasion (LVI) on disease control and survival has not been clarified.

Methods

The medical records of all early-stage OSCC patients who underwent curative surgery between 2004 and 2009 were reviewed.

Results

A total of 442 early stage patients were included in this study. There were 360 patients in group A (without PNI or LVI) and 82 patients in group B (with PNI and/or LVI). Between groups A and B patients, there were no significant differences in the 5-year disease-free survival (73.8 vs 68.7 %, p = 0.48) and overall survival (90.9 vs 86.1 %, p = 0.25). Between groups A and B patients without postoperative radiotherapy (PORT), there were no significant differences in the 5-year disease-free survival (73.8 vs 70.2 %, p = 0.51) and overall survival (90.9 vs 85.2 %, p = 0.18). Between group B patients with and without PORT, there was no significant difference in either the disease-free survival (61.1 vs 70.2 %, p = 0.98) and overall survival (88.9 vs 85.2 %, p = 0.64). Multivariate analyses revealed that PNI, LVI, and PORT could not provide significant effect on treatment outcome.

Conclusions

PNI and LVI were not significant risk factors for the disease control and overall survival for early stage OSCC patients. Furthermore, PORT could not provide an additional benefit for the disease control and overall survival for stages I and II OSCC patients with PNI and/or LVI.

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References

  1. Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefèbvre JL, Greiner RH, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350:1945–52.

    Article  PubMed  CAS  Google Scholar 

  2. Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350:1937–44.

    Article  PubMed  Google Scholar 

  3. Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, et al. Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29:167–78.

    Article  PubMed  Google Scholar 

  4. Chen TC, Wang CP, Ko JY, Yang TL, Lou PJ. The impact of pathologic close margin on the survival of patients with early stage oral squamous cell carcinoma. Oral Oncol. 2012;48:623–8.

    Article  PubMed  Google Scholar 

  5. Jones HB, Sykes A, Bayman N, Sloan P, Swindell R, Patel M, et al. The impact of lymphovascular invasion on survival in oral carcinoma. Oral Oncol. 2009;45:10–5.

    Article  PubMed  CAS  Google Scholar 

  6. Pindborg JJ, Reichart PA, Smith CJ, van der Waal I. World Health Organisation histological typing of cancer and precancer of the oral mucosa. 2nd ed. New York: Springer; 1997.

    Book  Google Scholar 

  7. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, editors. AJCC cancer staging manual. 6th ed. New York: Springer; 2002.

    Google Scholar 

  8. National Comprehensive Cancer Network clinical practice guidelines in oncology, head and neck cancers, V. I. 2012. http://www.nccn.org/. Accessed 8 Aug 2012.

  9. Fagan JJ, Collins B, Barnes L, D’Amico F, Myers EN, Johnson JT. Perineural invasion in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124:637–40.

    PubMed  CAS  Google Scholar 

  10. Soo KC, Carter RL, O’Brien CJ, Barr L, Bliss JM, Shaw HJ. Prognostic implications of perineural spread in squamous carcinomas of the head and neck. Laryngoscope. 1986;96:1145–8.

    Article  PubMed  CAS  Google Scholar 

  11. Rahima B, Shingaki S, Nagata M, Saito C. Prognostic significance of perineural invasion in oral and oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2004;97:423–31.

    Article  Google Scholar 

  12. Woolgar JA. Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. Oral Oncol. 2006;42:229–39.

    Article  PubMed  Google Scholar 

  13. Woolgar JA, Scott J. Prediction of cervical lymph node metastasis in squamous cell carcinoma of the tongue/floor of mouth. Head Neck. 1995;17:463–72.

    Article  PubMed  CAS  Google Scholar 

  14. Tadbir AA, Ashraf MJ, Sardari Y. Prognostic significance of stromal eosinophilic infiltration in oral squamous cell carcinoma. J Craniofac Surg. 2009;20:287–9.

    Article  PubMed  Google Scholar 

  15. Liao CT, Chang JT, Wang HM, Ng SH, Hsueh C, Lee LY, et al. Does adjuvant radiation therapy improve outcomes in pT1-3N0 oral cavity cancer with tumor-free margins and perineural invasion? Int J Radiat Oncol Biol Phys. 2008;71:371–6.

    Article  PubMed  Google Scholar 

  16. Close LG, Burns DK, Reisch J, Schaefer SD. Microvascular invasion in cancer of the oral cavity and oropharynx. Arch Otolaryngol Head Neck Surg. 1987;113:1191–5.

    Article  PubMed  CAS  Google Scholar 

  17. Mandal M, Myers JN, Lippman SM, Johnson FM, Williams MD, Rayala S, et al. Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features. Cancer. 2008;112:2088–100.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgment

This work was supported in part by the National Science Council of the Republic of China (NSC 98-2314-B-002-046-MY3), National Taiwan University Hospital, Yun-Lin Branch (NTUHYL101.M003), and Cancer Registry, Medical Information Management Office, NTUH.

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Authors and Affiliations

  1. Department of Otolaryngology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

    Tseng-Cheng Chen MD, Cheng-Ping Wang MD, Jeng-Yuh Ko MD, PhD, Tsung-Lin Yang MD, PhD, Chun-Wei Hsu MD, Kuo-An Yeh MD & Pei-Jen Lou MD, PhD

  2. Department of Otolaryngology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan

    Tseng-Cheng Chen MD, Chun-Wei Hsu MD & Kuo-An Yeh MD

  3. Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, Taiwan

    Tseng-Cheng Chen MD & Yih-Leong Chang MD, PhD

  4. Department of Pathology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

    Yih-Leong Chang MD, PhD

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  1. Tseng-Cheng Chen MD
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  2. Cheng-Ping Wang MD
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  3. Jeng-Yuh Ko MD, PhD
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  4. Tsung-Lin Yang MD, PhD
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  6. Kuo-An Yeh MD
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  7. Yih-Leong Chang MD, PhD
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  8. Pei-Jen Lou MD, PhD
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Corresponding author

Correspondence to Pei-Jen Lou MD, PhD.

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Chen, TC., Wang, CP., Ko, JY. et al. The Impact of Perineural Invasion and/or Lymphovascular Invasion on the Survival of Early-Stage Oral Squamous Cell Carcinoma Patients. Ann Surg Oncol 20, 2388–2395 (2013). https://doi.org/10.1245/s10434-013-2870-4

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  • DOI: https://doi.org/10.1245/s10434-013-2870-4

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