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Laparoscopic Sentinel Node Biopsy in Cervical Cancer Using a Combined Detection: 5–Years Experience

  • Gynecologic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

To evaluate the feasibility after 5 years experience of a laparoscopic sentinel node (SN) procedure with combined radioisotopic and patent blue labeling in patients with cervical cancer.

Methods

Sixty-seven patients (median age 48.9 years) with cervical cancer underwent a laparoscopic SN procedure using an endoscopic gamma probe, after both radioactive and patent blue injections. After the procedure, all the patients underwent complete laparoscopic pelvic/para-aortic lymphadenectomy.

Results

At least one SN was identified in 57 patients (85.1%). According to the Stage, the SN identification rate was 91.2% in early-stage cervical cancer and 78.5% in locally advanced cervical cancer. The mean number of SN was 2.3 per patient (range 1–5). A total of 129 SNs were removed. Lymph node metastasis involvement was identified in the 20 SNs (15.5%) from 14 patients (24.6%). Nine of the 14 patients had at least one macrometastases, three patients presented micrometastases in H&S, and two patients presented isolated single cells. Six patients presented a pelvic non-SN involvement including two patients whose SNs were uninvolved. The false-negative SNs rate was 12.5% (two patients out of 16). Both patients have locally advanced cervical cancer.

Conclusion

This study confirms that laparoscopic SN detection with a combination of radiocolloid and patent blue is accurate in patients with early cervical cancer to assess pelvic lymph node status.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, 4 rue de la Chine, 75020, Paris, France

    Charles Coutant MD, Yann Delpech MD, PhD, Serge Uzan MD, Emile Daraï MD, PhD & Emmanuel Barranger MD

  2. Department of Obstetrics and Gynecology, Hôpital Lariboisiere, Assistance Publique des Hôpitaux de Paris, 2 rue Ambroise-Paré, 75010, Paris, France

    Olivier Morel MD & Emmanuel Barranger MD

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  1. Charles Coutant MD
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  2. Olivier Morel MD
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  3. Yann Delpech MD, PhD
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  4. Serge Uzan MD
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  6. Emmanuel Barranger MD
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Correspondence to Emmanuel Barranger MD.

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Coutant, C., Morel, O., Delpech, Y. et al. Laparoscopic Sentinel Node Biopsy in Cervical Cancer Using a Combined Detection: 5–Years Experience. Ann Surg Oncol 14, 2392–2399 (2007). https://doi.org/10.1245/s10434-007-9424-6

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  • DOI: https://doi.org/10.1245/s10434-007-9424-6

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