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Subareolar and peritumoral injection identify similar sentinel nodes for breast cancer

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Abstract

Background

Sentinel lymph node (SLN) mapping with radioisotope and blue dye is rapidly becoming the standard of care for breast cancer. The optimal location for injection of radioisotope and blue dye is still being investigated. The goal of this study was to determine whether blue dye injection into the subareolar (SA) location localized the same sentinel nodes as the peritumoral (PT) location for patients with breast cancer.

Methods

Three hundred thirty-two patients with biopsy-proven operable breast cancer or ductal carcinoma in situ at two institutions underwent SLN mapping. Eighty-three patients had PT injection of blue dye (group 1), and 249 patients had SA injection of blue dye (group 2). All patients underwent PT injection of99mTc-labeled sulfur colloid.

Results

The two groups were similar in age, previous biopsy type, and tumor size, location, and histology. The mean number of SLNs identified was 2.4 (range, 0–9) in group 1 and 2.5 (range, 0–11) in group 2. The SLN identification rate was 95% for group 1 and 97% for group 2. The isotope success rate was 94% for both groups. The blue dye success rate was 84% for group 1 and 90% for group 2. The isotope/blue dye concordance rate was 87% for group 1 and 90% for group 2. At a median follow-up of 28 months (range, 14 to 40), there were no axillary recurrences in any of the 332 patients.

Conclusions

These data suggest that delivery of mapping reagents in the SA and PT locations identifies similar lymph nodes. Because of simplicity and the similarity in node identification between SA and PT injection, further investigation of the SA site for delivery of SLN mapping reagents for breast cancer is warranted.

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Authors and Affiliations

  1. Department of Surgery, University of Pennsylvania, 3400 Spruce St., Pennsylvania

    Todd W. Bauer MD, Francis R. Spitz MD, Linda S. Callans MD, Isabelle Bedrosian MD, Douglas L. Fraker MD & Brian J. Czerniecki MD, PhD

  2. Department of Nuclear Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

    Abass Alavi MD

  3. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania

    Susan P. Weinstein MD

  4. Department of Biostatistics and Epidemiology School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

    Rosemarie Mick MS

  5. Department of Surgery, York Hospital, York, Pennsylvania

    Thomas L. Bauer MD

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  1. Todd W. Bauer MD
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  2. Francis R. Spitz MD
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  3. Linda S. Callans MD
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  4. Abass Alavi MD
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  9. Thomas L. Bauer MD
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  10. Brian J. Czerniecki MD, PhD
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Correspondence to Brian J. Czerniecki MD, PhD.

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Bauer, T.W., Spitz, F.R., Callans, L.S. et al. Subareolar and peritumoral injection identify similar sentinel nodes for breast cancer. Annals of Surgical Oncology 9, 169–176 (2002). https://doi.org/10.1007/BF02557370

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  • DOI: https://doi.org/10.1007/BF02557370

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