Clinical InvestigationCorrelation of Epidermal Growth Factor Receptor With Morphological Features of Colorectal Advanced Adenomas: A Pilot Correlative Case Series
Section snippets
Genesis of This Report—Initial Case
A 63-year-old man presented with iron-deficiency anemia without any family history of colon cancer. On colonoscopy, 8 polypoid lesions were identified and removed. The 2 largest polyps were a single 5.5-cm thick-stalked polyp at the hepatic flexure and a 2-cm pedunculated polyp at the splenic flexure. The 6 other polyps varied from 0.3 to 1 cm in size. A colonoscopy 3 months later showed 5 other small polyps (3–5 mm) in different parts of the colon. All polyps were studied for immunohistochemical
Patient Characteristics
The following results are based on the analysis of the colon adenomas from 16 additional patients. The polyps from the initial patient have not been included in the final analysis. The analyzed population included 16 patients with age ranging from 50 to 82 years. All patients were men, and 13 were whites. The indications for colonoscopy were screening in 8, surveillance in 6, weight loss and hematochezia in 1 each. None of the patients had a family or personal history of colon cancer. A total
DISCUSSION
Encouraged by the findings in our index case and the putative role of EGFR in CRC pathogenesis, in the current pilot case series, we compared the expression of EGFR with some of the morphological features that characterize advanced adenomas. EGFR belongs to a family of plasma membrane receptor tyrosine kinases and controls many important cellular functions from proliferation and angiogenesis to cell death.6., 7. EGFR has been implicated in the pathogenesis of colon cancer8 and is associated
ACKNOWLEDGMENTS
The authors acknowledge the photographic assistance of Dennis Friesen, the technical assistance of the Kansas City VA Pathology and Histology Laboratory and the secretarial assistance of Peggy Knaus.
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Epidermal growth factor receptor (EGFR) gene copy number in colorectal adenoma-carcinoma progression
2012, Cancer GeneticsCitation Excerpt :Recently, Fichera and colleagues showed that the EGFR signaling pathway is required for the formation of microadenomas in a mouse model of colonic carcinogenesis (8). In human adenomas, overexpression of EGFR has been rarely investigated; immunohistochemistry has been used and results have been controversial and inconclusive (10–13). In this work, we have addressed the deregulation of the EGFR pathway during colonic carcinogenesis by investigating EGFR GCN by FISH (16–19).
Thermostable direct hemolysin diminishes tyrosine phosphorylation of epidermal growth factor receptor through protein kinase C dependent mechanism
2012, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Interfering with the activation of EGFR and its family members (ErbB-2/HER-2, ErbB-3/HER-3, and ErbB-4/HER-4) marks a promising strategy for developing targeted therapies against a vast array of epithelial cancers, because of their prevalence in different neoplastic cells. The overexpression of epidermal growth factor receptor and its other family members in several kinds of tumours determines the rationale for this kind of strategy [20–23]. Our previous paper [6] has established that thermostable direct hemolysin (TDH) of V. parahaemolyticus aids in down regulating the cell proliferation in colon carcinoma cell lines.
The molecular biology of colorectal carcinoma and its implications: A review
2011, SurgeonCitation Excerpt :Increased expression of EGFR has been associated with advanced stage and even metastasis and has been noted in almost 70% of advanced stage colorectal cancers.93 The expression of EGFR is highest deep within the tumour and correlates with the invasiveness of the tumour.94 The nature of EGFR expression in malignant colorectal tissue therefore makes it suitable not only as a potential prognostic marker but also as a possible therapeutic target.
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Presented in abstract form at the annual meeting of the College of American Pathologists, Chicago, IL, October 2007 (Arch Pathol Lab Med 2007;131:1432).