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Optical imaging of Cerenkov light generation from positron-emitting radiotracers

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Published 27 July 2009 2009 Institute of Physics and Engineering in Medicine
, , Citation R Robertson et al 2009 Phys. Med. Biol. 54 N355 DOI 10.1088/0031-9155/54/16/N01

0031-9155/54/16/N355

Abstract

Radiotracers labeled with high-energy positron emitters, such as those commonly used for positron emission tomography studies, emit visible light immediately following decay in a medium. This phenomenon, not previously described for these imaging tracers, is consistent with Cerenkov radiation and has several potential applications, especially for in vivo molecular imaging studies. Herein we detail a new molecular imaging tool, Cerenkov Luminescence Imaging, the experiments conducted that support our interpretation of the source of the signal, and proof-of-concept in vivo studies that set the foundation for future application of this new method.

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