Simultaneous molecular and anatomical imaging of the mouse in vivo

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Published 3 December 2002 Published under licence by IOP Publishing Ltd
, , Citation Andrew L Goertzen et al 2002 Phys. Med. Biol. 47 4315 DOI 10.1088/0031-9155/47/24/301

0031-9155/47/24/4315

Abstract

Non-invasive imaging technologies are opening up new windows into mouse biology. We have developed a mouse imaging system that integrates positron emission tomography (PET) with x-ray computed tomography (CT), allowing simultaneous anatomic and molecular imaging in vivo with the potential for precise registration of the two image volumes. The x-ray system consists of a compact mini-focal x-ray tube and an amorphous selenium flat panel x-ray detector with a low-noise CMOS readout. The PET system uses planar arrays of lutetium oxyorthosilicate scintillator coupled to position-sensitive photomultiplier tubes. We describe the design of this dual-modality imaging system and show, for the first time, simultaneously acquired PET and CT images in a phantom and in mice.

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10.1088/0031-9155/47/24/301