Exp Clin Endocrinol Diabetes 2001; Vol. 109(1): 56-59
DOI: 10.1055/s-2001-11020
Mini-Review

© Johann Ambrosius Barth

Approaches to gene therapy with sodium/iodide symporter

C. Spitzweg, J. C. Morris
  • Division of Endocrinology, Mayo Clinic & Medical School, Rochester, MN, USA
Further Information

Publication History

Publication Date:
31 December 2001 (online)

Summary:

Since cloning and characterization of the sodium iodide symporter (NIS) gene, several investigators explored the possibility of a novel cytoreductive gene therapy strategy based on NIS gene transfer into non-thyroidal tumor cells followed by radioiodine therapy. NIS gene transfer has been shown to be capable of inducing radioiodine accumulation in vitro and in vivo in several non-thyroidal cancer cell lines. Following PSA promoter-mediated NIS gene delivery we were able to demonstrate prostate-specific iodide accumulation in prostate cancer cells that was high enough to elicit a therapeutic response of 131-I in vitro and in vivo. This study clearly demonstrates the potential of NIS as a novel therapeutic gene for non-thyroidal cancers, in particular prostate cancer.

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Christine SpitzwegM.D. 

Mayo Clinic

Endocrine Research Unit

Guggenheim 625 200 First Street SW

Rochester, MN 55905

USA

Phone: 507-284-2324

Fax: 507-284-4521

Email: spitzweg.christine@mayo.edu

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