Regular Article
6-oxo-PGFand 8-epi-PGFin human atherosclerotic vascular tissue

https://doi.org/10.1054/plef.1998.0019Get rights and content

Abstract

Isoprostanes are a new family of compounds generated by the free radical catalyzed action on arachidonic acid. Formed during oxidation they have been claimed to be a reliable indicator of in vivo oxidation injury. We assessed the amount of 8-epi-PGFin human surgical specimens as compared to PGI2(via its stable metabolite 6-oxo-PGF), the major compound generated by vascular tissue. 8-epi-PGFis low in normal vascular tissue as is the 8-epi-PGF/6-oxo-PGFratio. The vessels of smokers in general exhibited an increased 8-epi-PGF(r=0.82) and a decreased 6-oxo-PGF(r=0.71). The 8-epi-PGF/6-oxo-PGFratio is, not significantly, increased in vessels derived from hyperlipidemics and hypertensives. These findings indicate that lipid peroxidation occurs within the human arterial wall as evidenced by 8-epi-PGF, probably further decreasing the synthesis of PGI2and promoting atherogenic mechanisms.

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