Guest editorial: The conception of FDG-PET imaging

doi:10.1053/snuc.2002.29269

Seminars in Nuclear Medicine

Volume 32, Issue 1, January 2002, Pages 2-5

https://doi.org/10.1053/snuc.2002.29269 Get rights and content

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Nonetheless, oncometabolism research never faded away completely, with a small number of researchers pursuing this line of research, namely Efraim Racker who, in 1972, coined the term Warburg effect to describe the presence of high aerobic fermentation in tumors [36]. A major breakthrough in the field of oncometabolism occurred in the 1980s, when positron emission tomography (PET) using the fluorinated glucose analogue 2-18fluoro-2-deoxy-d-glucose (FDG) was implemented in the clinic for cancer imaging [37], after animal studies confirmed its exquisite sensitivity to measure the altered metabolism of tumors [38]. This metabolic imaging technique takes advantage of the abnormally high glucose uptake of cancers, in accordance with the increased demands of an energy metabolism over-reliant on fermentation.
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