Guest editorial: The conception of FDG-PET imaging
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2021, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Nonetheless, oncometabolism research never faded away completely, with a small number of researchers pursuing this line of research, namely Efraim Racker who, in 1972, coined the term Warburg effect to describe the presence of high aerobic fermentation in tumors [36]. A major breakthrough in the field of oncometabolism occurred in the 1980s, when positron emission tomography (PET) using the fluorinated glucose analogue 2-18fluoro-2-deoxy-d-glucose (FDG) was implemented in the clinic for cancer imaging [37], after animal studies confirmed its exquisite sensitivity to measure the altered metabolism of tumors [38]. This metabolic imaging technique takes advantage of the abnormally high glucose uptake of cancers, in accordance with the increased demands of an energy metabolism over-reliant on fermentation.
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2020, PET ClinicsCitation Excerpt :About 80 years after Vesalius, William Harvey published De motu cordis, and for the first time showed how to observe experimental measurement of physiologic function. By a strange coincidence, about 80 years after Roentgen’s discovery, the first molecular and physiologic imaging using 18F-fluorodeoxyglucose (FDG) and the rectilinear scanner set the course toward PET.1–3 Molecular imaging awakened clinicians to noninvasive imaging of disease pathophysiology.4
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