Positron emission tomography in lung cancer
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<sup>18</sup>F-Fluoro-2-Deoxy-D-Glucose PET/Computed Tomography Evaluation of Lung Cancer in Populations with High Prevalence of Tuberculosis and Other Granulomatous Disease
2018, PET ClinicsCitation Excerpt :Therefore, a simple view of the metabolic degree of the lesions is not enough, and it is therefore very important that the morphology of the lesion with high radioactivity uptake on 18F-FDG PET imaging should also be taken into consideration. Numerous studies have reported on the use of 18F-FDG PET imaging in the diagnosis of SPN and lung tumor.42–44 Gould and colleagues45 in their meta-analysis found that for pulmonary lesions, the overall sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 18F-FDG PET imaging were approximately 96%, 78%, 91%, and 92%, respectively.
Physiology and Pathophysiology of Incidental Findings Detected on FDG-PET Scintigraphy
2010, Seminars in Nuclear MedicineCitation Excerpt :Areas of increased uptake in the marrow, thymus, and lymphoid tissues reflects the degree of posttherapy stimulation within these sites. Increased FDG uptake may persist in surgical sites or irradiated tissue up to 6 months after conclusion of treatment.146 The tumor itself may exhibit transient decrease in uptake or increase in uptake (flare)147 because of therapy and not reflecting ultimate tumor status.
Positron Emission Tomography/Computed Tomography Potential Pitfalls and Artifacts
2009, Current Problems in Diagnostic RadiologyCitation Excerpt :Although 18F-FDG-PET imaging can detect occult relapse of colorectal cancer in 65% of patients with rising carcinoembryonic antigen (CEA) levels but no obvious site of tumor recurrence,43 it may not be able to differentiate postsurgical inflammation and tumor recurrence. FDG may be accumulated in irradiated tissues and postsurgical inflammatory changes up to 6 months after the end of treatment.44 PET/CT provides both functional and anatomic information in a single imaging study.
Follow-up and surveillance of the lung cancer patient following curative intent therapy: ACCP evidence-based clinical practice guideline (2nd edition)
2007, ChestCitation Excerpt :In addition, uptake on PET scans has been reported in the pleura of the shielded, nonirradiated lung even in the absence of overt radiation pneumonitis.89 It has been recommended that PET scans for evaluating recurrent disease not be performed after curative intent therapy for at least 3 to 6 months to minimize the possibility of false-positive findings, and that suspicious lesions on a surveillance PET scan be confirmed by CT imaging and biopsy.82, 90 Importantly, there are no data showing that incorporating PET scanning into a surveillance program improves either survival or quality of life following curative intent therapy for NSCLC.
Improvement in sensitivity with delayed imaging of pulmonary lesions with FDG-PET
2007, Revista Espanola de Medicina NuclearClinical implications of defining the gross tumor volume with combination of CT and <sup>18</sup>FDG-positron emission tomography in non-small-cell lung cancer
2007, International Journal of Radiation Oncology Biology Physics