Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor alpha gene transfer
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Induction of Antitumor Response by In Vivo Allogeneic Major Histocompatibility Complex Gene Transfer Using Electroporation
2009, Journal of Surgical ResearchCitation Excerpt :On the other hand, others have attempted to modify tumor cells to enhance tumor antigenicity [17–19]. Several previous studies have demonstrated that transfection of cytokine genes, such as tumor necrosis factor-α [20, 21], interferon-γ (IFN-γ) [22–25], interleukin-2 [26–28], or interleukin-4 [29] into the tumor cells induced an antitumor effect, resulting in tumor regression in animal studies and human trials [30]. In recent reports, new approaches using T-cell receptor gene transfer to exploit allogeneic T-cell repertoires have been investigated [1, 31].
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