Original Investigations: Pathogenesis and Treatment of Kidney Disease and HypertensionDynamic renal blood flow measurement by positron emission tomography in patients with CRF*,**,★
Section snippets
Procedure
PET measurements were performed before and 5, 40, 80, and 120 minutes after the injection of quinaprilat, 10 mg intravenously (active metabolite of quinapril; Parke Davis, Courbevoie, France). Inulin and PAH clearances were measured during two 30-minute periods for baseline value. Another 25-minute measurement was performed starting 5 minutes before quinaprilat injection and ending 20 minutes after the injection, followed by three 40-minute periods (20 to 60 minutes, 60 to 100 minutes, 100 to
PET-RBF
PET measurement was performed successfully in all patients. An example of PET images is shown in Fig 1.
Discussion
This study is the first report of the ability of PET to measure dynamically RBF in patients with CRF. It shows that a single intravenous injection of an ACE inhibitor induces a significant increase in PET-RBF. It shows that PET is a reliable method for measuring RBF in humans and may be more sensitive than PAH clearance for detecting acute RBF changes in humans.
In this study, PET and PAH clearances both measured low RBF, as expected in patients with CRF. Normal cortical blood flow is estimated
Acknowledgements
The authors thank D. Comar and J.F. Pujol, CERMEP Directors; Gérard Galy, Véronique Berthier, Franck Lavenne, Christian Pierre, Dorothée Parisot, Christine Vighi, Martine Lionnet, Marie Christine Lamure, Laurent Veyre, and Fréderic Bonnefoi for pertinent advice and technical assistance; Dr Varennes (Laboratoire de Biochimie, Hôpital Edouard Herriot) for measuring ACE activity in this study; and Carlos Romero, Lilach Lerman, Luis Juncos (Physiology and Biophysics, Mayo Clinic, Rochester, MN) and
References (20)
- et al.
Can the IVIM model be used for renal perfusion imaging?
Eur J Radiol
(1998) - et al.
Renal blood flow measurement by positron emission tomography using 15O labeled water
Kidney Int
(2000) - et al.
Influence of the level of hydration on the renal response to a protein meal
Kidney Int
(1992) - et al.
A continuous spectrophotometric assay for angiotensin converting enzyme
Anal Biochem
(1979) ACE inhibitors in renal disease
Kidney Int
(1992)- et al.
Angiotensin II local hyperreactivity in the progression of IgA nephropathy
Am J Kidney Dis
(1993) - et al.
Drug-induced changes in renal hippurate clearance as a measure of renal blood flow
Kidney Int
(1995) - et al.
Quantification and parametric imaging of renal cortical blood flow in vivo based on Patlak graphical analysis
Kidney Int
(1993) - et al.
Noninvasive evaluation of a novel swine model of renal artery stenosis
J Am Soc Nephrol
(1999) Procedures of choice in renal nuclear medicine
J Nucl Med
(1991)
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Basic principles and new advances in kidney imaging
2021, Kidney InternationalCitation Excerpt :PET, a reference standard for quantitative cortical perfusion,26 also allows molecular imaging.27 PET has been used successfully in patients with renovascular disease,28 renal allografts,29 and CKD.30 The combined PET/CT modality provides detailed morphology in addition to molecular function and is thus particularly powerful for assessments of renal perfusion and metabolism.
Contrast Ultrasound and Targeted Microbubbles: Diagnostic and Therapeutic Applications in Progressive Diabetic Nephropathy
2012, Seminars in NephrologyCitation Excerpt :Although increases in plasma renal flow, coupled with glomerular hyperfiltration, occurs early in type 1 diabetes,5 as nephropathy progresses hyperglycemia induces expansion of the mesangial matrix leading to capillary compression and endothelial cell injury and loss,6 with reductions in glomerular filtration rate. Many imaging techniques can be used to assess renal perfusion, including ultrasound imaging, nuclear medicine techniques,7 computerized tomography, and magnetic resonance imaging.8 Comparisons between techniques are beyond the scope of the present review, and are available via other excellent focused reviews.8,9
Contribution of X-ray computed tomography in the evaluation of kidney performance
2012, Nephrologie et TherapeutiqueRenal Perfusion, Oxygenation and Metabolism: The Role of Imaging
2023, Journal of Clinical MedicineLong-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
2022, Journal of Visualized Experiments
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Supported in part by Parke Davis, France.
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Address reprint requests to Laurent Juillard, MD, PhD, Hôpital Edouard Herriot, Pavillon P, 3 place D'Arsonval, 69437 Lyon Cedex 03, France. E-mail: [email protected]
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