Original articleThe streptozotocin-diabetic rat as a model of the chronic complications of human diabetes☆
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2022, Acta BiomaterialiaCitation Excerpt :To mimic the post-menopausal status in women who receive mesh implantations and minimize the impact of estrogen variability, we performed bilateral ovariectomy at the time of mesh implantation. Streptozotocin (STZ) was used to selectively destroy pancreatic β cells, thereby induce diabetes with hyperglycemia as the major attribute [26–29]. We hypothesized that diabetes dysregulates the vaginal immune response to mesh, leading to an increased and prolonged inflammation at the mesh-tissue interface.
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Presented at the International Society for Heart Research and International Union of Physiological Societies World Congress Satellite Meeting, Models of Cardiovascular Disease, 2–4 September 2001, Brisbane, Australia.
Copyright © 2003 Published by Elsevier Ltd. on behalf of The Australasian Society of Cardiac and Thoracic Surgeons and The Cardiac Society of Australia and New Zealand