Harvesting 18F-fluoride ions in water via direct 18F–19F isotopic exchange: radiofluorination of zwitterionic aryltrifluoroborates and in vivo stability studies

Zibo Li; Kantapat Chansaenpak; Shuanglong Liu; Casey R. Wade; Peter S. Conti; François P. Gabbaï

doi:10.1039/C2MD20105D

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Harvesting ¹⁸F-fluoride ions in watervia direct ¹⁸F–¹⁹F isotopic exchange: radiofluorination of zwitterionic aryltrifluoroborates and in vivo stability studies†

Zibo Li,‡*^a Kantapat Chansaenpak,§^b Shuanglong Liu,§^a Casey R. Wade,§^b Peter S. Conti^a and François P. Gabbaï ‡*^b

Author affiliations

* Corresponding authors

^a Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
E-mail: ziboli@usc.edu

^b Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA
E-mail: gabbai@mail.chem.tamu.edu

Abstract

In this report, we show that [¹⁸F]-zwitterionic aryltrifluoroborates with ortho-phosphonium groups are: (i) easily accessible via direct ¹⁸F–¹⁹F isotopic exchange reactions in aqueous solutions; and (ii) efficiently stabilized in vivo against fluoride ion dissociation.

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Article information

DOI: https://doi.org/10.1039/C2MD20105D
Article type: Concise Article
Submitted: 27 Apr 2012
Accepted: 14 Aug 2012
First published: 05 Sep 2012

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Med. Chem. Commun., 2012,3, 1305-1308

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Harvesting ¹⁸F-fluoride ions in water via direct ¹⁸F–¹⁹F isotopic exchange: radiofluorination of zwitterionic aryltrifluoroborates and in vivo stability studies

Z. Li, K. Chansaenpak, S. Liu, C. R. Wade, P. S. Conti and F. P. Gabbaï, Med. Chem. Commun., 2012, 3, 1305 DOI: 10.1039/C2MD20105D

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