Issue 23, 2010

Orthogonal 18F and 64Culabelling of functionalised bis(thiosemicarbazonato) complexes

Abstract

The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of 18F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

Graphical abstract: Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

Supplementary files

Article information

Article type
Communication
Submitted
23 Dec 2009
Accepted
24 Mar 2010
First published
20 Apr 2010

Chem. Commun., 2010,46, 4052-4054

Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

L. Carroll, R. Bejot, R. Hueting, R. King, P. Bonnitcha, S. Bayly, M. Christlieb, J. R. Dilworth, A. D. Gee, J. Declerck and V. Gouverneur, Chem. Commun., 2010, 46, 4052 DOI: 10.1039/B926980K

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