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Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT

Molecular Psychiatry volume 12, pages 984–987 (2007)Cite this article

Abstract

A pivotal question in neuropharmacology is how the function of neurotransmitter systems relates to psychiatric diseases. In experimental neuropharmacology, we have dreamt about a looking glass that would allow us to see neurotransmitter systems in action, and about animals that would faithfully serve us as models for human psychiatric disease. Analysis of animal models has been limited by the availability of methods to study in vivo neurotransmitter dynamics. Now, a single photon emission computed tomography system called U-SPECT can localize dopamine transporters in sub-compartments of the mouse brain during a range of points in time. Applied to the midbrain dopamine system of different models of disease, this will aid the understanding of dynamic processes of this neurotransmitter that underlie brain functions and human brain pathology.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands

    B Vastenhouw, F van der Have & F J Beekman

  2. Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands

    B Vastenhouw, F van der Have, A J A van der Linden, L von Oerthel, J P H Burbach, M P Smidt & F J Beekman

  3. Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    J Booij

Authors
  1. B Vastenhouw
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  2. F van der Have
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  3. A J A van der Linden
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  4. L von Oerthel
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  5. J Booij
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  6. J P H Burbach
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  7. M P Smidt
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Correspondence to F J Beekman.

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Vastenhouw, B., van der Have, F., van der Linden, A. et al. Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT. Mol Psychiatry 12, 984–987 (2007). https://doi.org/10.1038/sj.mp.4002028

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  • DOI: https://doi.org/10.1038/sj.mp.4002028

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