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Infections Post Transplant

Association of cytomegalovirus interstitial pneumonitis with HLA-type following allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 25, pages 861–865 (2000)Cite this article

Abstract

Certain human leukocyte antigens may increase the risk of cytomegalovirus interstitial pneumonitis, an important complication of bone marrow transplantation. The prevalence of this pneumonitis was compared between patients possessing either HLA-B51 or HLA-B52 and patients without either antigen. The role of tumor necrosis factor-α in cytomegalovirus interstitial pneumonitis was also studied. Among 72 patients undergoing allogeneic bone marrow transplantation at our institution during the past 5 years, HLA-B51 or -B52 was detected in 29. Among these 29 patients, 13 (45%) developed cytomegalovirus interstitial pneumonitis, a significantly higher rate (P < 0.001) than among patients without these hla types (4/43, 9%). in the pre-conditioning and stable phases, tumor necrosis factor-α levels were higher in patients with hla-b51 or hla-b52 than in patients without (P < 0.05; t-test). Throughout the period from pre-conditioning to around day 40, except on day 0, tumor necrosis factor-α levels were also significantly higher (P < 0.05 to P < 0.001) in patients developing cytomegalovirus infection than in those without it. these results suggest that hla-b51 and hla-b52 may be risk factors for cytomegalovirus interstitial pneumonitis after bone marrow transplantation, with an increase of tumor necrosis factor-α also being involved. Bone Marrow Transplantation (2000) 25, 861–865.

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Acknowledgements

We wish to thank Ms A Utsumi and Ms Y Shikita for their expert technical assistance.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

    S Yamada, H Takatsuka, Y Takemoto, T Okamoto, Y Fujimori, S Tamura, H Wada, M Okada & E Kakisita

  2. Third Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan

    A Kanamaru

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Yamada, S., Takatsuka, H., Takemoto, Y. et al. Association of cytomegalovirus interstitial pneumonitis with HLA-type following allogeneic bone marrow transplantation. Bone Marrow Transplant 25, 861–865 (2000). https://doi.org/10.1038/sj.bmt.1702244

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