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Thresholds of replication stress signaling in cancer development and treatment

Nature Structural & Molecular Biology volume 19, pages 5–7 (2012)Cite this article

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Oncogene-induced replication stress and DNA damage are among the hallmarks of cancer. A recent study explores how different levels of replication stress affect animal development and tumorigenesis, and how targeting of the replication stress–signaling pathway of ATR and Chk1 kinases can be exploited for selective killing of cancer cells.

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Figure 1: Impact of different levels of ATR signaling on organismal development and tumorigenesis.
Figure 2: Distinct roles of the ATR-Chk1 pathway during multistep tumorigenesis.
Figure 3: Potential exploitation of replication stress as a target for cancer therapy.

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Acknowledgements

The authors are supported by grants from the Danish Cancer Society, the Danish National Research Foundation, the Czech Ministry of Health (NS10282-3/2009, NT11065-5/2010), the Czech Ministry of Education (MSM6198959216) and the European Commission (projects Infla-Care, Biomedreg and DDResponse).

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Authors and Affiliations

  1. Jiri Bartek and Jirina Bartkova are at the Centre for Genotoxic Stress Research, Danish Cancer Society, Copenhagen, Denmark.,

    Jiri Bartek & Jirina Bartkova

  2. Martin Mistrik and Jiri Bartek are at the Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic.,

    Jiri Bartek & Martin Mistrik

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  1. Jiri Bartek
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Correspondence to Jiri Bartek.

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Bartek, J., Mistrik, M. & Bartkova, J. Thresholds of replication stress signaling in cancer development and treatment. Nat Struct Mol Biol 19, 5–7 (2012). https://doi.org/10.1038/nsmb.2220

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