Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuro-oncology

Amino acid PET for brain tumours — ready for the clinic?

The Response Assessment in Neuro-Oncology Working Group has analysed the role of clinically established PET methods in the diagnostic assessment of brain tumours. The group emphasizes the clinical value of PET imaging, particularly amino acid PET imaging, over conventional MRI, and recommends its use at every stage of management.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Tovi, M., Hartman, M., Lilja, A. & Ericsson, A. MR imaging in cerebral gliomas. Tissue component analysis in correlation with histopathology of whole-brain specimens. Acta Radiol. 35, 495–505 (1994).

    Article  CAS  PubMed Central  Google Scholar 

  2. Ryken, T. C. et al. The role of imaging in the management of progressive glioblastoma: a systematic review and evidence-based clinical practice guideline. J. Neurooncol. 118, 435–460 (2014).

    Article  CAS  PubMed Central  Google Scholar 

  3. Wen, P. Y. et al. Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J. Clin. Oncol. 28, 1963–1972 (2010).

    Article  Google Scholar 

  4. Albert, N. L. et al. Response Assessment in Neuro-Oncology working group and European Association for Neuro-Oncology recommendations for the clinical use of PET imaging in gliomas. Neuro Oncol. http://dx.doi.org/10.1093/neuonc/now058 (2016).

  5. Rapp, M. et al. Clinical value of O-(2-[18F]-fluoroethyl)-L-tyrosine positron emission tomography in patients with low-grade glioma. Neurosurg. Focus 34, E3 (2013).

    Article  PubMed Central  Google Scholar 

  6. Galldiks, N. et al. The use of dynamic O-(2-18F-fluoroethyl)-L-tyrosine PET in the diagnosis of patients with progressive and recurrent glioma. Neuro Oncol. 17, 1293–1300 (2015).

    Article  CAS  PubMed Central  Google Scholar 

  7. Singhal, T., Narayanan, T. K., Jain, V., Mukherjee, J. & Mantil, J. 11C-L-methionine positron emission tomography in the clinical management of cerebral gliomas. Mol. Imaging Biol. 10, 1–18 (2008).

    Article  PubMed Central  Google Scholar 

  8. Langen, K. J., Tonn, J. C., Weller, M. & Galldiks, N. Letter to the editor: “The role of imaging in the management of progressive glioblastoma. A systematic review and evidence-based clinical practice guideline” [J Neurooncol 2014; 118:435–460]. J. Neurooncol. 120, 665–666 (2014).

    Article  PubMed Central  Google Scholar 

  9. Swiss Agency for Therapeutic Products. New registrations, products for use in humans. J. Swissmed. 13, 651 (2014).

  10. Heinzel, A., Stock, S., Langen, K. J. & Muller, D. Cost-effectiveness analysis of FET PET-guided target selection for the diagnosis of gliomas. Eur. J. Nucl. Med. Mol. Imaging 39, 1089–1096 (2012).

    Article  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Both authors contributed equally to all aspects of the article.

Corresponding authors

Correspondence to Karl-Josef Langen or Colin Watts.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Langen, KJ., Watts, C. Amino acid PET for brain tumours — ready for the clinic?. Nat Rev Neurol 12, 375–376 (2016). https://doi.org/10.1038/nrneurol.2016.80

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2016.80

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer