Abstract
Cetuximab (Erbitux; ImClone Systems/Bristol-Myers Squibb) is a monoclonal antibody that binds to the epidermal growth factor receptor, which is important in the growth of many cancers. In February 2004, it was granted accelerated approval by the FDA for the treatment of metastatic colorectal cancer on the basis of tumour response rates in Phase II trials.
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References
Parkin, D. M. et al. Cancer burden in the year 2000. The global picture. Eur. J. Cancer 37, S4–S66 (2001).
Baselga, J. The EGFR as a target for anticancer therapy — focus on cetuximab. Eur. J. Cancer 37, S16–S22 (2001).
Dancey, J. & Sausville, E. A. Issues and progress with protein kinase inhibitors for the treatment of cancer. Nature Rev. Drug Discov. 2, 296–313 (2003).
Salomon, D. S. et al. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19, 183–232 (1995).
Goldstein, N. I. et al. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer. Res. 1, 1311–1318 (1995).
FDA labelling information [online] (cited 6 May 2004) <http://www.fda.gov/cder/foi/label/2004/125084lbl.pdf> (2004).
Prewett, M. C. et al. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin. Cancer Res. 8, 994–1003 (2002).
Yarden, Y. & Sliwkowski, M. X. Untangling the ErbB signalling network. Nature Rev. Mol. Cell Biol. 2, 127–137 (2001).
Burtness, B. A. et al. Phase III trial comparing cisplatin (C) + placebo (P) to C + anti-epidermal growth factor antibody (EGF-R) C225 in patients (pts) with metastatic/recurrent head & neck cancer (HNC). Proc. Am. Soc. Clin. Oncol. 21, 226a (2002).
Caponigro, F. et al. New cytotoxic and molecular-targeted therapies of head and neck tumors. Curr. Opin. Oncol. 16, 225–230 (2004).
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Kirkpatrick, P., Graham, J. & Muhsin, M. Cetuximab. Nat Rev Drug Discov 3, 549–550 (2004). https://doi.org/10.1038/nrd1445
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DOI: https://doi.org/10.1038/nrd1445