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PARP inhibition: PARP1 and beyond

Nature Reviews Cancer volume 10, pages 293–301 (2010)Cite this article

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Abstract

Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents.

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Figure 1: Structural and functional characteristics of PARP1.

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Acknowledgements

The authors are supported by research funds from a Canada research chair in proteomics, the Canadian Institutes of Health Research (CIHR grants MOP-74648 and IG1-14052), the Cancer Research Society, the Alberta Cancer Board and the National Institutes of Health (NIH grant P50 CA136393-01).

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Authors and Affiliations

  1. Michèle Rouleau and Guy G. Poirier are at the Laval University Medical Research Center, Laval University, Québec, Canada.,

    Michèle Rouleau & Guy G. Poirier

  2. Anand Patel is at the Department of Molecular Pharmacology and Experimental Therapeutics, the Mayo Clinic, Rochester, Minnesota, USA.,

    Anand Patel

  3. Scott H. Kaufmann is at the Division of Oncology Research and the Department of Molecular Pharmacology and Experimental Therapeutics, the Mayo Clinic, Rochester, Minnesota, USA.,

    Scott H. Kaufmann

  4. Michael J. Hendzel is at the Department of Oncology, Faculty of Medicine, University of Alberta and Cross Cancer Institute, Alberta, Canada.,

    Michael J. Hendzel

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  1. Michèle Rouleau
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Correspondence to Guy G. Poirier.

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DATABASES

National Cancer Institute Drug Dictionary 

AG014699

BSI-201

carboplatin

gemcitabine

olaparib

temozolomide

OMIM

http://www.ncbi.nlm.nih.gov/omim

Protein Data Base 

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Rouleau, M., Patel, A., Hendzel, M. et al. PARP inhibition: PARP1 and beyond. Nat Rev Cancer 10, 293–301 (2010). https://doi.org/10.1038/nrc2812

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