Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • On the Market
  • Published:

Bioluminescent indicators in living mammals

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Contag, C., et al. Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 66, 523–531 (1997).

    Article  CAS  Google Scholar 

  2. Contag, C.H., Contag, P.R., Spilman, S.D., Stevenson, D.K. & Benaron, D.A. Photonic monitoring of infectious disease and gene regulation, in OSA TOPS on Biomedical Optical Spectroscopy and Diagnostics, (eds. Sevick-Muraca, E. & Benaron, D.) 220–224 (Optical Society of America, Washington, DC, 1996).

    Google Scholar 

  3. Contag, C.H., et al. Photonic detection of bacterial pathogens in a living host. Molec. Micro. 18, 593–603 (1995).

    Article  CAS  Google Scholar 

  4. Thompson, E.M., Adenot, P., Tsuji, F.I. & Renard, J.P. Real-time imaging of transcriptional activity in live mouse preimplantation embryos using a secreted luciferase. Proc. Natl. Acad. Sci. USA 92, 1317–1321 (1995).

    Article  CAS  Google Scholar 

  5. Hooper, C.E., Ansorge, R.E. & Rushbrooke, J.G. Low-light imaging technology in the life sciences. J. Biolumin. Chemilumin. 9, 113–122 (1994).

    Article  CAS  Google Scholar 

  6. Hooper, C.E., Ansorge, R.E., Browne, H.M. & Tomkins, P. CCD imaging of luciferase gene expression in single mammalian cells. J. Biolumin. Chemilumin. 5, 123–130 (1990).

    Article  CAS  Google Scholar 

  7. White, M.R.H., et al. Real-time analysis of the transcriptional regulation of HIV and hCMV promoters in single mammalian cells, J. Cell Sci. 108, 441–455 (1995).

    CAS  PubMed  Google Scholar 

  8. Petterson, J., et al. Modulation of virulence factor expression by pathogen target cell contact. Science 273, 1231–1233 (1996).

    Article  Google Scholar 

  9. Morrey, J.D., Bourn, S.M., Bunch, T.D., Sidwell, R.W. & Rosen, C.A. HIV-1 LTR activation model: Evaluation of various agents in skin of transgenic mice. J. Acquir. Immune Defic. Syndr. 5, 1195–1203 (1992).

    Article  CAS  Google Scholar 

  10. Morrey, j.D., et al. In vivo activation of human immunodeficiency virus type 1 long terminal repeat by UV type A (UV-A) light plus psoralen and UV-B light in the skin of transgenic mice. J. Virol. 65, 5045–5051 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Zhang, L., Hellstrom, K.E. & Chen, L. Luciferase activity as a marker of tumor burden and as an indicator of tumor response to antineoplastic therapy in vivo. Clin. Exp. Metastasis 12, 87–92 (1994).

    Article  CAS  Google Scholar 

  12. Hickey, M.J., et al. Luciferase in vivo expression technology: Use of recombinant mycobacterial reporter strains to evaluate antimycobacterial activity in mice. Antimicrob. Agents Chemother. 40, 400–407 (1996).

    Article  CAS  Google Scholar 

  13. Morrey, J.D., Bourn, S.M., Morris, J.L., Bunch, T.D. & Sidwell, R.W. Activation of the human immunodeficiency virus long terminal repeat by abrasion of the skin in transgenic mice. Intervirology 37, 315–320 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Contag, P., Olomu, I., Stevenson, D. et al. Bioluminescent indicators in living mammals. Nat Med 4, 245–247 (1998). https://doi.org/10.1038/nm0298-245

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0298-245

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing