Abstract
The pathogenesis of metastasis begins with the invasion of tissues, blood vessels and/or lymphatics by cells originating from a primary cancer. Following their release into the circulation, most tumour emboli are initially arrested in the first capillary bed encountered, but some recirculate and are trapped in other organs. After their initial arrest, tumour cells must invade the parenchyma, establish a micro-environment, escape host defence mechanisms and finally grow into secondary tumours1.
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FIDLER, I. Selection of Successive Tumour Lines for Metastasis. Nature New Biology 242, 148–149 (1973). https://doi.org/10.1038/newbio242148a0
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DOI: https://doi.org/10.1038/newbio242148a0
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