Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Viewpoint
  • Published:

Molecular imaging can accelerate anti-angiogenic drug development and testing

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Gambhir SS (2002) Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer 2: 683–693

    Article  CAS  Google Scholar 

  2. Cai W et al. (2006) How molecular imaging is speeding up antiangiogenic drug development. Mol Cancer Ther 5: 2624–2633

    Article  CAS  Google Scholar 

  3. Brooks PC et al. (1994) Requirement of vascular integrin αvβ3 for angiogenesis. Science 264: 569–571

    Article  CAS  Google Scholar 

  4. Haubner R et al. (2001) Noninvasive imaging of αvβ3 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res 61: 1781–1785

    CAS  PubMed  Google Scholar 

  5. Haubner R et al. (2005) Noninvasive visualization of the activated αvβ3 integrin in cancer patients by positron emission tomography and [18F]galacto-RGD. PLoS Med 2: e70

    Article  Google Scholar 

  6. Beer AJ et al. (2006) Positron emission tomography using [18F]Galacto-RGD identifies the level of integrin αvβ3 expression in man. Clin Cancer Res 12: 3942–3949

    Article  CAS  Google Scholar 

  7. Chen X et al. (2004) Micro-PET imaging of αvβ3-integrin expression with 18F-labeled dimeric RGD peptide. Mol Imaging 3: 96–104

    Article  CAS  Google Scholar 

  8. Li S et al. (2003) Imaging gastrointestinal tumours using vascular endothelial growth factor-165 (VEGF165) receptor scintigraphy. Ann Oncol 14: 1274–1277

    Article  CAS  Google Scholar 

  9. Cai W et al. (2006) PET of vascular endothelial growth factor receptor expression. J Nucl Med 47: 2048–2056

    CAS  PubMed  Google Scholar 

  10. Backer MV et al. (2007) Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat Med 13: 504–509

    Article  CAS  Google Scholar 

  11. Czernin J et al. (2006) Molecular imaging in the development of cancer therapeutics. Annu Rev Med 57: 99–118

    Article  CAS  Google Scholar 

  12. Mulder WJ et al. (2007) Early in vivo assessment of angiostatic therapy efficacy by molecular MRI. FASEB J 21: 378–383

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sanjiv Sam Gambhir.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Iagaru, A., Chen, X. & Gambhir, S. Molecular imaging can accelerate anti-angiogenic drug development and testing. Nat Rev Clin Oncol 4, 556–557 (2007). https://doi.org/10.1038/ncponc0929

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncponc0929

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing