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Fate of Bacteriophage Lambda in Non-immune Germ-free Mice

Nature volume 246, pages 221–223 (1973)Cite this article

Abstract

THE clearance of colloidal particles in animals has been studied in several experiments1–16. The use of bacteriophage in such studies offers a sensitive tool to augment materials such as dyes, radioactive colloids and enzymes for analysing mechanisms of handling foreign particulate material. Furthermore, such use of bacterial viruses may enhance the general understanding of virus–host interactions.

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References

  1. Biozzi, G., Benacerraf, B., and Halpern, B. N., Br. J. exp. Path., 34, 441 (1953).

    CAS  Google Scholar 

  2. Uhr, J. W., and Weissmann, G., J. Immun., 94, 544 (1965).

    CAS  PubMed  Google Scholar 

  3. Williams, G. M., and Nossal, G. J. V., J. exp. Med., 124, 47 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Williams, G. M., J. exp. Med., 124, 57 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Nossal, G. J. V., Austin, C. M., Pye, J., and Mitchell, J., Int. Arch. Allerg., 29, 368 (1966).

    Article  CAS  PubMed  Google Scholar 

  6. Szakal, A. K., and Hanna, M. G., Exp. molec. Path., 8, 75 (1968).

    Article  CAS  PubMed  Google Scholar 

  7. Hanna, M. G., Francis, M. W., and Peters, L. C., Immunology, 15, 75 (1968).

    PubMed  PubMed Central  Google Scholar 

  8. Unanue, E. R., and Askonas, B. A., J. exp. Med., 127, 915 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Hanna, M. G., and Szakal, A. K., J. Immun., 101, 949 (1968).

    PubMed  Google Scholar 

  10. Fisher, S., Riley, W. B., and Shorey, C. D., J. path. Bact., 96, 463 (1968).

    Article  CAS  PubMed  Google Scholar 

  11. Inchley, C. J., Clin. exp. Immun., 5, 173 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Burke, J. S., and Simon, G. T., Am. J. Path., 58, 157 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Herscowitz, H. B., and Stelos, P. J., J. Immun., 105, 779 (1970).

    CAS  PubMed  Google Scholar 

  14. Herscowitz, H. B., and Stelos, P. J., J. Immun., 105, 771 (1970).

    CAS  PubMed  Google Scholar 

  15. Inchley, C. J., J. Immun., 104, 14 (1970).

    CAS  PubMed  Google Scholar 

  16. Van Rooijen, N., Immunology, 22, 757 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Inchley, C. J., and Howard, J. G., Clin. exp. Immun., 5, 189 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Brunner, K. T., Hurez, D., McCluskey, R. T., and Benacerraf, B., J. Immun., 85, 99 (1960).

    CAS  PubMed  Google Scholar 

  19. Caro, R. A., Ciscato, V. A., and Radsicella, R., Int. J. appl. Radiat. Isotopes, 21, 405 (1970).

    Article  CAS  Google Scholar 

  20. Feiss, M., Adyha, S., and Court, D. L., Genetics, 71, 189 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Pollard, M., Prog. med. Virol., 7, 362 (1965).

    CAS  PubMed  Google Scholar 

  22. de Harven, E., J. exp. Med., 120, 857 (1964).

    Article  CAS  PubMed Central  Google Scholar 

  23. Pollard, M., and Matsuzawa, T., Am. J. Path., 44, 17a (1964).

    Google Scholar 

  24. Pollard, M., Nature, 213, 142 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. Appleyard, R. K., Genetics, 39, 440 (1954).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Nash, H. A., and Merril, C. R., J. molec. Biol., 43, 357 (1969).

    Article  CAS  PubMed  Google Scholar 

  27. Reyniers, J. A., Am. J. vet. Res., 18, 678 (1957).

    CAS  PubMed  Google Scholar 

  28. Trexler, P. C., and Reynolds, L. I., Appl. Microbiol., 5, 406 (1957).

    CAS  PubMed  PubMed Central  Google Scholar 

  29. Pollard, M., Science N.Y., 145, 247 (1964).

    Article  ADS  CAS  Google Scholar 

  30. Gordon, H. A., Triangle, 7, 108 (1965).

    CAS  PubMed  Google Scholar 

  31. Adams, M. H., Bacteriophages, 971 (Interscience, 1959).

  32. Lukas, G., Brindle, S. D., and Greengard, P., J. Pharmac. exp. Ther., 178, 562 (1971).

    CAS  Google Scholar 

  33. Nagy, Z. A., Horrath, E., and Urban, Z., Nature new Biol., 242, 241 (1973).

    Article  CAS  PubMed  Google Scholar 

  34. Fishman, M., and Adler, F. L., J. exp. Med., 117, 595 (1963).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Fishman, M., Hammerstrom, R. A., and Bond, V. P., Nature, 198, 549 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  36. Fishman, M., and Adler, F. L., Cold Spring Harbor Symp. quant. Biol., 32, 343 (1967).

    Article  CAS  Google Scholar 

  37. Gottlieb, A. A., Glislin, V. R., and Doty, P., Proc. natn. Acad. Sci. U.S.A., 57, 1849 (1969).

    Article  ADS  Google Scholar 

  38. Aaskov, J. G., and Halliday, W. J., Cell Immun., 2, 335 (1971).

    Article  CAS  Google Scholar 

  39. Lavelle, G. C., Sturman, L., and Hadlow, W. J., Infect. Immun., 5, 319 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. D'Herrelle, F., The Bacteriophage and Its Clinical Applications (Thomas, Springfield, Illinois, 1930).

    Google Scholar 

  41. Merril, C. R., Geier, M. R., and Petricciani, J. C., Nature, 233, 398 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Geier, M. R., and Merril, C. R., Virology, 47, 638 (1972).

    Article  CAS  PubMed  Google Scholar 

  43. Kluge, T., and Hovig, T., Am. J. Path., 54, 355 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland, 20014

    MARK R. GEIER, MICHAEL E. TRIGG & CARL R. MERRIL

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  1. MARK R. GEIER
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  2. MICHAEL E. TRIGG
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  3. CARL R. MERRIL
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GEIER, M., TRIGG, M. & MERRIL, C. Fate of Bacteriophage Lambda in Non-immune Germ-free Mice. Nature 246, 221–223 (1973). https://doi.org/10.1038/246221a0

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