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Inhibition of the Extraneuronal Metabolism of Noradrenaline in the Isolated Heart by Adrenergic Blocking Agents

Nature volume 213, pages 297–298 (1967)Cite this article

Abstract

ADRENERGIC blocking agents inhibit the response of effector cells to noradrenaline and related amines1; several of these drugs also act as inhibitors of the uptake of noradrenaline into sympathetic nerves2,3. This communication describes a novel action of adrenergic blocking agents, the ability to inhibit the extraneuronal metabolism of noradrenaline in a peripheral tissue.

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Author notes

  1. ARNOLD J. EISENFELD

    Present address: Department of Pharmacology, Yale University Medical School, New Haven, Connecticut

  2. LESLIE L. IVERSEN

    Present address: Department of Pharmacology, University of Cambridge,

Authors and Affiliations

  1. Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

    ARNOLD J. EISENFELD, LAWRENCE KRAKOFF, LESLIE L. IVERSEN & JULIUS AXELROD

Authors
  1. ARNOLD J. EISENFELD
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  2. LAWRENCE KRAKOFF
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  3. LESLIE L. IVERSEN
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  4. JULIUS AXELROD
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EISENFELD, A., KRAKOFF, L., IVERSEN, L. et al. Inhibition of the Extraneuronal Metabolism of Noradrenaline in the Isolated Heart by Adrenergic Blocking Agents. Nature 213, 297–298 (1967). https://doi.org/10.1038/213297a0

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