Abstract
Objectives: The pain assocaited with ureteralobstruction is caused by a rise in intraluminalpressure above the obstruction which producesan increase in tension of the ureteral smoothmuscle. A reduction in pressure will result indecreased tension and relief of pain. In thisstudy we used papaverine and a prostaglandinsynthesis inhibitor, diclofenac sodium todecrease ureteral tension and compaired theireffects on isolated human ureteric smoothmuscle.Materials and methods: Experiment havebeen carried out with isolated ring preparationof human ureter. The tissue displayedspontaneous activity and contracted whenexposed to KCI (40 mM). Papaverine(10−5 M) and diclofenac sodium(10−8–10−5 M) were applied on theprecontracted segments and isometric variationwas recorded with Nihon-Kohden TB-612 isometrictransducer. Their relaxant responses werecomparatively examined.Results: Mean relaxation obtained bydiclofenac sodium and papaverine wererespectively 43.19% and 28.96%. Our studyshowed that diclofenac sodium may be morepotent than papaverine in the treatment ofrenal colic.
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Sivrikaya, A., Celik, O.F., Sivrikaya, N. et al. The effect of diclofenac sodium and papaverine on isolated human ureteric smooth muscle. Int Urol Nephrol 35, 479–483 (2003). https://doi.org/10.1023/B:UROL.0000025618.68752.5b
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DOI: https://doi.org/10.1023/B:UROL.0000025618.68752.5b