Skip to main content
SpringerLink
Log in

Oncogene mRNA imaging with 99mTc-chelator-PNA-peptides

  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

[99mTc]PNA-peptide conjugates capable of binding to IGF1 receptors will be synthesized. Specificity of their uptake and hybridization to mRNA in normal epithelial human cells compared to human breast cancer cells will be studied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. M. Namavari, J. R. Barrio, T. Toyokuni, S. S. Gambhir, S. R. Cherry, H. R. Herschman, M. E. Phelps, and Satyamurthy, Nucl. Med. Biol., 2000, 27, 157.

    Google Scholar 

  2. R. Hustinx, C. Y. Shiue, H. Zhuang, D. McDonald, M. Lanuti, E. Lambright, J. G. Smith, J. S. Karp, P. Lu, S. L. Eck, and A. A. Alavi, J. Nucl. Med., 2000, 41, 264.

    Google Scholar 

  3. V. Ponomarev, M. Dubrovin, J. Balatoni, R. Finn, R. G. Blasberg, and J. G. Tjuvajev, J. Nucl. Med., 2000, 41, 263.

    Google Scholar 

  4. R. T. Greenlee, T. Murray, S. Bolden, and P. A. Wingo, CA Cancer J. Clin., 2000, 50, 7.

    Google Scholar 

  5. C. J. Baines, in Fundamental Problems in Breast Cancer, Eds. H. G. Paterson and A. W. Lees, Marcus Nijhoff: Boston, 1987, 25.

    Google Scholar 

  6. K. J. Martin, B. M. Kritzman, L. M. Price, B. Koh, C. P. Kwan, X. Zhang, A. Mackay, M. J. O´Hare, C. M. Kaelin, G. L. Mutter, A. B. Pardee, and R. Sager, Cancer Res., 2000, 60, 2232.

    Google Scholar 

  7. J. M. Bishop, Cell, 1991, 64, 235.

    Google Scholar 

  8. E. R. Sauter, M. Herlyn, S. C. Liu, S. Litwin, and J. A. Ridge, Clin. Cancer Res., 2000, 6, 654.

    Google Scholar 

  9. J. P. Vaughn, J. D. Iglehart, S. Demirdji, P. Davis, L. E. Babiss, M. H. Caruthers, and J. R. Marks, Proc. Natl. Acad. Sci. USA, 1995, 92, 8338.

    Google Scholar 

  10. E. Wickstrom and F. L. Tyson, in Oligonucleotides as Therapeutic Agents, D. Chadwick and G. Cardew, Wiley: London, 1997, 209, 124; discussion 137.

    Google Scholar 

  11. E. L. Wickstrom, T. A. Bacon, A. Gonzalez, D. L. Freeman, G. H. Lyman, and E. Wickstrom, Proc. Natl. Acad. Sci. USA, 1988, 85, 1028.

    Google Scholar 

  12. E. Wickstrom, T. A. Bacon, and E. L. Wickstrom, Cancer Res., 1992, 52, 6741.

    Google Scholar 

  13. Y. Huang, R. Snyder, M. Kligshteyn, and E. Wickstrom, Molecular Medicine, 1995, 1, 647.

    Google Scholar 

  14. J. B. Smith and E. Wickstrom, J. Natl. Cancer Inst., 1998, 90, 1146.

    Google Scholar 

  15. M. R. Bishop, J. D. Jackson, S. R. Tarantolo, B. O´Kane-Murphy, P. L. Iversen, E. Bayever, S. M. Joshi, J. G. Sharp, J. L. Pierson, P. I. Warkentin, J. O. Armitage, and A. Kessinger, J. Hematotherapy, 1997, 6, 441.

    Google Scholar 

  16. E. Bayever, K. M. Haines, P. L. Iversen, R. W. Ruddon, S. J. Pirruccello, C. P. Mountjoy, M. A. Arneson, and L. J. Smith, Leukemia Lymphoma, 1994, 12, 223.

    Google Scholar 

  17. P. W. Hinds, S. F. Dowdy, E. N. Eaton, A. Arnold, and R. A. Weinberg, Proc. Natl. Acad. Sci. USA, 1994, 91, 709.

    Google Scholar 

  18. J. Bartkova, J. Lukas, H. Muller, M. Strauss, B. Gusterson, and J. Bartek, Cancer Res., 1995, 55, 949.

    Google Scholar 

  19. J. Adelaide, G. Monges, C. Derderian, J. F. Seitz, D. Birnbaum, Br. J. Cancer, 1995, 71, 64.

    Google Scholar 

  20. K. Helin and E. Harlow, Trends Cell Biol., 1992, 3, 43.

    Google Scholar 

  21. D. W. Goodrich and W.-H. Lee, Biochim. Biophys. Acta, 1993, 1155, 43.

    Google Scholar 

  22. J. R. Nevins, Science, 1992, 258, 424.

    Google Scholar 

  23. C. Deng, P. Zhang, J. W. Harper, S. J. Elledge, and P. Leder, Cell, 1995, 82, 675.

    Google Scholar 

  24. H. D. Matsushime, E. Quelle, S. A. Shurtleff, M. Shibuya, C. J. Sherr, and J.-Y. Kato, Mol. Cell Biol., 1994, 14, 2066.

    Google Scholar 

  25. A. Arnold, H. G. Kim, R. D. Gaz, R. L. Eddy, Y. Fukushima, M. G. Byers, T. B. Shows, and H. M. Kronenberg, J. Clin. Invest., 1989, 83, 2034.

    Google Scholar 

  26. T. Motokura and A. Arnold, Genes Chromosomes Cancer, 1993, 7, 89.

    Google Scholar 

  27. W. Jiang, S. M. Kahn, P. Zhou, Y. J. Zhang, A. M. Cacace, A. S. Infante, S. Doi, R. M. Santella, I. B. Weinstein, Oncogene, 1993, 8, 3447.

    Google Scholar 

  28. D. E. Quelle, R. A. Ashmun, S. A. Shurtleff, J. Y. Kato, D. Bar-Sagi, M. F. Roussel, and C. J. Sherr, Genes Dev., 1993, 7, 1559.

    Google Scholar 

  29. H. Lovec, A. Sewing, F. C. Lucibello, R. Muller, and T. Moroy, Oncogene, 1994, 9, 323.

    Google Scholar 

  30. M. S. Rieber and M. Rieber, Biochem. Biophys. Res. Commun., 1995, 216, 422.

    Google Scholar 

  31. C. B. Vos, N. T. Ter Haar, J. L. Peterse, C. J. Cornelisse, and M. J. van de Vijver, J. Pathol., 1999, 187, 279.

    Google Scholar 

  32. P. Collecchi, A. Passoni, M. Rocchetta, E. Gnesi, E. Baldini, and G. Bevilacqua, Int. J. Cancer, 1999, 84, 139.

    Google Scholar 

  33. T. Utsumi, N. Yoshimura, M. Maruta, S. Takeuchi, J. Ando, Y. Mizoguchi, and N. Harada, Int. J. Cancer, 2000, 89, 39.

    Google Scholar 

  34. F. S. Kenny, R. Hui, E. A. Musgrove, J. M. Gee, R. W. Blamey, R. I. Nicholson, R. L. Sutherland, and J. F. Robertson, Clin. Cancer Res., 1999, 5, 2069

    Google Scholar 

  35. E. R. Sauter, M. Nesbit, S. Litwin, A. J. Klein-Szanto, S. Cheffetz, and M. Herlyn, Cancer Res., 1999, 59, 4876.

    Google Scholar 

  36. D. J. Slamon, G. M. Clark, S. G. Wong, W. J. Levin, A. Ullrich, and W. L. McGuire, Science, 1987, 235, 177.

    Google Scholar 

  37. M. J. van de Vijver, J. L. Peterse, W. J. Mooi, P. Wisman, J. Lomans, O. Dalesio, and R. Nusse, N. Engl. J. Med., 1988, 319, 1239.

    Google Scholar 

  38. A. Stark, B. S. Hulka, S. Joens, D. Novotny, A. D. Thor, L. E. Wold, M. J. Schell, L. J. Melton, 3rd, E. T. Liu, and K. Conway, J. Clin. Oncol., 2000, 18, 267.

    Google Scholar 

  39. R. Goldman, R. B. Levy, E. Peles, and Y. Yarden, Biochemistry., 1990, 29, 11024.

    Google Scholar 

  40. A. L. Schechter, M. C. Hung, L. Vaidyanathan, R. A. Weinberg, T. L. Yang-Feng, U. Francke, A. Ullrich, and L. Coussens, Science, 1985, 229, 976.

    Google Scholar 

  41. M. H. Kraus, W. Issing, T. Miki, N. C. Popescu, and S. A. Aaronson, Proc. Natl. Acad. Sci. USA, 1989, 86, 9193.

    Google Scholar 

  42. M. Alimandi, A. Romano, M. C. Curia, R. Muraro, P. Fedi, S. A. Aaronson, P. P. Di Fiore, and M. H. Kraus, Oncogene, 1995, 10, 1813.

    Google Scholar 

  43. Y. Kokai, J. A. Cohen, J. A. Drebin, and M. I. Greene, Proc. Natl. Acad. Sci. USA, 1987, 84, 8498.

    Google Scholar 

  44. M. F. Press, M. C. Pike, V. R. Chazin, G. Hung, J. A. Udove, M. Markowicz, J. Danyluk, W. Godolphin, M. Sliwkowski, and R. Akita, Cancer Res., 1993, 53, 4960.

    Google Scholar 

  45. J. S. Ross and J. A. Fletcher, Oncologist, 1998, 3, 237.

    Google Scholar 

  46. M. A. Cobleigh, C. L. Vogel, and N. J. Tripathy, Proc. Am. Soc. Clin. Oncol., 1998, 17, 97.

    Google Scholar 

  47. D. Slamon, B. Leyland-Jones, and S. Shak, Proc. Am. Soc. Clin. Oncol., 1998, 17, 98.

    Google Scholar 

  48. J. Bertram, M. Killian, W. Brysch, K. Schlingensiepen, and M. Kneba, Biochem. Biophys. Res. Commun., 1994, 200, 661.

    Google Scholar 

  49. J. P. Vaughn, J. Stekler, S. Demirdji, J. K. Mills, M. H. Caruthers, J. D. Iglehart, and J. R. Marks, Nucleic Acids Res., 1996, 24, 4558.

    Google Scholar 

  50. K. F. Pirollo, Z. Hao, A. Rait, C. W. Ho, and E. H. Chang, Biochem. Biophys. Res. Commun., 1997, 230, 196.

    Google Scholar 

  51. E. M. Berns, J. G. Klijn, W. L. van Putten, I. L. van Staveren, H. Portengen, and J. A. Foekens, Cancer Res., 1992, 52, 1107.

    Google Scholar 

  52. E. M. Blackwood and R. N. Eisenman, Science, 1991, 251, 1211.

    Google Scholar 

  53. K. H. Moberg, T. J. Logan, W. A. Tyndall, and D. J. Hall, Oncogene, 1992, 7, 411.

    Google Scholar 

  54. K. H. Moberg, W. A. Tyndall, and D. J. Hall, J. Cell Biochem., 1992, 49, 208.

    Google Scholar 

  55. E. Wickstrom, Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS, Wiley-Liss, New York, 1991.

    Google Scholar 

  56. J. B. Smith and E. Wickstrom, Methods Enzymol., 2000, 314, 537.

    Google Scholar 

  57. P. H. Watson, R. T. Pon, and R. P. Shiu, Cancer Res., 1991, 51, 3996.

    Google Scholar 

  58. L. Meng, L. Lin, H. Zhang, M. Nassiri, A. R. Morales, and M. Nadji, Mutat. Res., 1999, 435, 263.

    Google Scholar 

  59. A. D. Thor, D. H. Moore, II, S. M. Edgerton, E. S. Kawasaki, E. Reihsaus, H. T. Lynch, J. N. Marcus, L. Schwartz, L. C. Chen, and B. H. Mayall, J. Natl. Cancer Inst., 1992, 84, 845.

    Google Scholar 

  60. A. D. Thor, D. A. Berry, D. R. Budman, H. B. Muss, T. Kute, I. C. Henderson, M. Barcos, C. Cirrincione, S. Edgerton, C. Allred, L. Norton, and E. T. Liu, J. Natl. Cancer Inst., 1998, 90, 1346.

    Google Scholar 

  61. Z. Tong, G. Singh, and A. J. Rainbow, Photochem. Photobiol., 2000, 71, 201.

    Google Scholar 

  62. M. Gurnani, P. Lipari, J. Dell, B. Shi, and L. L. Nielsen, Cancer Chemother. Pharmacol., 1999, 44, 143.

    Google Scholar 

  63. J. Nemunaitis, S. G. Swisher, T. Timmons, D. Connors, M. Mack, L. Doerksen, D. Weill, J. Wait, D. D. Lawrence, B. L. Kemp, F. Fossella, B. S. Glisson, W. K. Hong, F. R. Khuri, J. M. Kurie, J. J. Lee, J. S. Lee, D. M. Nguyen, J. C. Nesbitt, R. Perez-Soler, K. M. Pisters, J. B. Putnam, W. R. Richli, D. M. Shin, G. L. Walsh, and J. Merritt, J. Clin. Oncol., 2000, 18, 609.

    Google Scholar 

  64. W. C. Broaddus, Y. Liu, L. L. Steele, G. T. Gillies, P. S. Lin, W. G. Loudon, K. Valerie, R K. Schmidt-Ullrich, and H. L. Fillmore, J. Neurosurg., 1999, 91, 997.

    Google Scholar 

  65. L. Xu, K. F. Pirollo, W. H. Tang, A. Rait, and E. H. Chang, Hum. Gene Ther., 1999, 10, 2941.

    Google Scholar 

  66. A. M. Belikova, V. F. Zarytova, and N. I. Grineva, Tetrahedron Lett., 1967, 37, 3557.

    Google Scholar 

  67. P. C. Zamecnik and M. L. Stephenson, Proc. Natl. Acad. Sci. USA, 1978, 75, 280.

    Google Scholar 

  68. S. Agrawal, Antisense Therapeutics, Humana Press, Totowa NJ, 1996.

    Google Scholar 

  69. E. Wickstrom, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors, Marcel Dekker, New York, 1998.

    Google Scholar 

  70. P. T. Ho, K. Ishiguro, E. Wickstrom, and A. C. Sartorelli, Antisense Research and Development, 1991, 1, 329.

    Google Scholar 

  71. S. Agrawal, Trends in Biotechnology, 1996, 14, 376.

    Google Scholar 

  72. B. P. Monia, E. A. Lesnik, C. Gonzalez, W. F. Lima, D. McGee, C. J. Guinosso, A. M. Kawasaki, P. D. Cook, and S. M. Freier, J. Biol. Chem., 1993, 268, 14514.

    Google Scholar 

  73. S. Agrawal, Z. Jiang, Q. Zhao, D. Shaw, Q. Cai, A. Roskey, L. Channavajjala, C. Saxinger, and R. Zhang, Proc. Natl. Acad. Sci. USA, 1997, 94, 2620.

    Google Scholar 

  74. S. Basu and E. Wickstrom, Bioconjugate Chem., 1997, 8, 481.

    Google Scholar 

  75. T. M. Tan, B. W. Kalisch, J. H. van de Sande, R. C. Ting, and Y. H. Tan, Antisense Nucleic Acid Drug Dev., 1998, 8, 95.

    Google Scholar 

  76. J. M. Aramini and M. W. Germann, Biochem. Cell Biol., 1998, 76, 403.

    Google Scholar 

  77. V. K. Rait and B. R. Shaw, Antisense Nucleic Acid Drug Dev., 1999, 9, 53.

    Google Scholar 

  78. B. R. Shaw, D. Sergueev, K. He, K. Porter, J. Summers, Z. Sergueeva, and V. Rait, Methods Enzymol., 2000, 313, 226.

    Google Scholar 

  79. S. Basu and E. Wickstrom, Tetrahedron Lett., 1995, 36, 4943.

    Google Scholar 

  80. J. Hughes, A. Astriab, H. Yoo, S. Alahari, E. Liang, D. Sergueev, B. R. Shaw, and R. L. Juliano, Methods Enzymol., 2000, 313, 342.

    Google Scholar 

  81. C. Marwick, JAMA, 1998, 280, 871.

    Google Scholar 

  82. R. Y. Walder and J. A. Walder, Proc. Natl. Acad. Sci. USA, 1988, 85, 5011.

    Google Scholar 

  83. M. A. Stalteri and S. J. Mather, Nucl. Med. Commun., 2000, 21, 374.

    Google Scholar 

  84. M. L. Thakur, V. R. Pallela, P. M. Consigny, P. S. Rao, D. Vessileva-Belnikolovska, and R. Shi, J. Nucl. Med., 2000, 41, 161.

    Google Scholar 

  85. M. L. Thakur, C. S. Marcus, S. Saeed, V. Pallela, C. Minami, L. Diggles, H. Le Pham, R. Ahdoot, and E. A. Kalinowski, J. Nucl. Med., 2000, 41, 107.

    Google Scholar 

  86. P. S. Rao, M. L. Thakur, V. Pallela, R. Patti, K. Reddy, H. Li, S. Sharma, H. L. Pham, L. Diggles, C. Minami, and C. S. Marcus, Nucl. Med. Biol., 2001, 28, 445.

    Google Scholar 

  87. P. S. Rao, V. R. Pallela, D. Vassileva-Belnikolovska, D. Jungkind, and M. L. Thakur, Nucl. Med. Commun., 2000, 21, 1063.

    Google Scholar 

  88. M. Eisenhut and U. Haberkorn, Eur. J. Nucl. Med., 2000, 27, 1589.

    Google Scholar 

  89. W. Mier, R. Eritja, A. Mohammed, U. Haberkorn, and M. Eisenhut, Bioconjugate Chem., 2000, 11, 855.

    Google Scholar 

  90. W. Mier, R. Eritja, A. Mohammed, U. Haberkorn, and M. Eisenhut, J. Labelled Comp. Radiopharm., 2001, 42, 115.

    Google Scholar 

  91. V. R. Pallela, M. L. Thakur, S. Chakder, and S. Rattan, J. Nucl. Med., 1999, 40, 352.

    Google Scholar 

  92. V. R. Pallela, M. L. Thakur, P. M. Consigny, P. S. Rao, D. Vasileva-Belnikolavska, and R. Shi, Thromb. Res., 1999, 93, 191.

    Google Scholar 

  93. J. C. Reubi, J. Nucl. Med., 1995, 36, 1825.

    Google Scholar 

  94. J. C. Hanvey, N. J. Peffer, J. E Bisi, S. A. Thomson, R. Cadilla, J. A. Josey, D. J. Ricca, C. F. Hassman, M. A. Bonham, and K. G. Au, Science, 1992, 258, 1481.

    Google Scholar 

  95. M. A. Bonham, S. Brown, A. L. Boyd, P. H. Brown, D. A. Bruckenstein, J. C. Hanvey, S. A. Thomson, A. Pipe, F. Hassman, and J. E. Bisi, Nucleic Acids Res., 1995, 23, 1197.

    Google Scholar 

  96. G. D. Gray, S. Basu, and E. Wickstrom, Biochem. Pharmacol., 1997, 53, 1465.

    Google Scholar 

  97. L. Good and P. E. Nielsen, Proc. Natl. Acad. Sci. USA, 1998, 95, 2073.

    Google Scholar 

  98. R. Baserga, Cancer Res., 1995, 55, 249.

    Google Scholar 

  99. W. Arap, R. Pasqualini, and E. Ruoslahti, Science, 1998, 279, 377.

    Google Scholar 

  100. Z. Pietrzkowski, D. Wernicke, P. Porcu, B. A. Jameson, and R. Baserga, Cancer Res., 1992, 52, 6447.

    Google Scholar 

  101. Z. Pietrzkowski, C. Sell, R. Lammers, A. Ullrich, and R. Baserga, Mol. Cell Biol., 1992, 12, 3883.

    Google Scholar 

  102. R. B. Lal, D. L. Rudolph, T. M. Folks, and W. C. Hooper, Leuk. Res., 1993, 17, 31.

    Google Scholar 

  103. M. Egholm, O. Buchardt, L. Christensen, C. Behrens, S. M. Freier, D. A. Driver, R. H. Berg, S. K. Kim, B. Norden, and P. E. Nielsen, Nature, 1993, 365, 566.

    Google Scholar 

  104. A. Ullrich, A. Gray, A. W. Tam, T. Yang-Feng, M. Tsubokawa, C. Collins, W. Henzel, T. Le Bon, S. Kathuria, and E. Chen, EMBO J., 1986, 5, 2503.

    Google Scholar 

  105. L. C. Boffa, S. Scarfi, M. R. Mariani, G. Damonte, V. G. Allfrey, U. Benatti, and P. L. Morris, Cancer Res., 2000, 60, 2258.

    Google Scholar 

  106. L. Good and P. E. Nielsen, Antisense Nucleic Acid Drug Dev., 1997, 7, 431.

    Google Scholar 

  107. S. Basu, H. R. Kolan, M. L. Thakur, and E. Wickstrom, J. Labeled Comp. Radiopharm., 1995, 37, 350.

    Google Scholar 

  108. X. Le Roy, C. Escot, J. P. Brouillet, C. Theillet, T. Maudelonde, J. Simony-Lafontaine, H. Pujol, and H. Rochefort, Oncogene, 1991, 6, 431.

    Google Scholar 

  109. H. J. van Slooten, B. A. Bonsing, A. J. Hiller, G. T. Colbern, J. H. van Dierendonck, C. J. Cornelisse, and H. S. Smith, Br. J. Cancer, 1995, 72, 22.

    Google Scholar 

  110. P. M. Holland, R. D. Abramson, R. Watson, and D. H. Gelfand, Proc. Natl. Acad. Sci. USA, 1991, 88, 7276.

    Google Scholar 

  111. M. M. Kennedy, S. Biddolph, S. B. Lucas, D. D. Howells, S. Picton, J. O. McGee, I. Silva, V. Uhlmann, K. Luttich, and J. J. O´Leary, J. Clin. Pathol., 1999, 52, 569.

    Google Scholar 

  112. I. Bièche, P. Onody, I. Laurendeau, M. Olivi, D. Vidaud, R. Lidereau, and M. Vidaud, Clin. Chem., 1999, 45, 1148.

    Google Scholar 

  113. I. Bièche, I. Laurendeau, S. Tozlu, M. Olivi, D. Vidaud, R. Lidereau, and M. Vidaud, Cancer Res., 1999, 59, 2759.

    Google Scholar 

  114. I. Arany, A. Yen, and S. K. Tyring, Anticancer Res., 1997, 17, 1281.

    Google Scholar 

  115. Y. Daaka and E. Wickstrom, Oncogene Res., 1990, 5, 267.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    E. Wickstrom & X. Tian

  2. Department of Radiology, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    E. Wickstrom, X. Tian, P. S. Rao, M. L. Thakur, W. Qin & E. R. Sauter

  3. Department of Surgery, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    P. S. Rao & M. L. Thakur

  4. Kimmel Cancer Center, Thomas Jefferson University, 19107, Philadelphia, PA, USA

    W. Qin & E. R. Sauter

Authors
  1. E. Wickstrom
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. X. Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. S. Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. L. Thakur
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. Qin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. R. Sauter
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wickstrom, E., Tian, X., Rao, P.S. et al. Oncogene mRNA imaging with 99mTc-chelator-PNA-peptides. Russian Chemical Bulletin 51, 1083–1099 (2002). https://doi.org/10.1023/A:1020985420948

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1020985420948

Search

Navigation