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Inflammatory Bowel Disease Activity Assessment Using Technetium-99m-HMPAO Leukocytes

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Abstract

Aim of the study was to evaluate[99mTc]hexamethyl-propylamine-oxime (HMPAO)leukocyte scintigraphy for the assessment of diseaseactivity and extent in inflammatory bowel diseasepatients. Results and scores of scintigraphy using[99Tc]HMPAO-labeled leukocytes wereretrospectively compared with the activity index of vanHees, laboratory parameters, and gastroenterologists'assessment of disease using endoscopy, radiology, and histology plusclinical parameters in 136 patients with Crohn's disease(115) and ulcerative colitis (21) and in 29 controls.There were 114 positive and 22 negative[99Tc]HMPAO leukocyte scintigrams. Sensitivities for activedisease at 1 and 3 hr were 98% and 98% and specificitieswere 100% and 83%, respectively. [99mTc]HMPAOleukocyte scintigraphy is superior to the activity index and the gastroenterologists' clinicalassessment of active inflammation in IBD patients.Scintigraphy allows assessment of the existence, extent,and intensity of active inflammation in IBD patients in one examination with highaccuracy.

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Authors
  1. J.-W. Arndt
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  2. M.I. Grootscholten
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  3. R. A. Van Hogezand
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  4. G. Griffioen
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  5. C.B.H.W. Lamers
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  6. E.K.J. Pauwels
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Arndt, JW., Grootscholten, M., Van Hogezand, R.A. et al. Inflammatory Bowel Disease Activity Assessment Using Technetium-99m-HMPAO Leukocytes. Dig Dis Sci 42, 387–393 (1997). https://doi.org/10.1023/A:1018834406637

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  • DOI: https://doi.org/10.1023/A:1018834406637

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