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Prostate-specific Membrane Antigen (PSMA)-specific Monoclonal Antibodies in the Treatment of Prostate and Other Cancers

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Abstract

Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein that is expressed by prostate epithelial cells. PSMA-specific monoclonal antibodies have been utilized to characterize the biologic function and in vivo biodistribution of PSMA. PSMA is an attractive target protein for monoclonal antibody directed imaging or therapeutics for prostate cancer since its expression is relatively restricted to prostate epithelial cells and is over-expressed in prostate cancer, including in advanced stages. Currently, clinical usage of PSMA specific monoclonal antibodies has been limited to diagnostic immunohistochemistry and imaging of patients with prostate cancer. Novel applications for these antibodies will be discussed.

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References

  1. Horoszewicz JS, Kawinski E, Murphy GP: Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients. Anticancer Res 7: 927–35, 1987

    Google Scholar 

  2. Israeli RS, Powell CT, Fair WR, Heston WD: Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res 53: 227–30, 1993

    Google Scholar 

  3. Israeli RS, Powell CT, Corr JG, Fair WR, Heston WD: Expression of the prostate-specific membrane antigen. Cancer Res 54: 1807–11,1994

    Google Scholar 

  4. Rinker-Schaeffer CW, Hawkins AL, Su SL, Israeli RS, Griffin CA, Isaacs JT, Heston WD: Localization and physical mapping of the prostate-specific membrane antigen (PSM) gene to human chromosome 11. Genomics 30: 105–8, 1995

    Google Scholar 

  5. Leek J, Lench N, Maraj B, Bailey A, Carr IM, Andersen S, Cross J, Whelan P, MacLennan KA, Meredith DM, Markham AF: Prostate-specific membrane antigen: evidence for the existence of a second related human gene. Br J Cancer 72: 583–8, 1995

    Google Scholar 

  6. O'Keefe DS, Su SL, Bacich DJ, Horiguchi Y, Luo Y, Powell CT, Zandvliet D, Russell PJ, Molloy PL, Nowak NJ, Shows TB, Mullins C, Vonder Haar RA, Fair WR, Heston WD: Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene. Biochim Biophys Acta 1443: 113–27, 1998

    Google Scholar 

  7. Pinto JT, Suffoletto BP, Berzin TM, Qiao CH, Lin S, Tong WP, May F, Mukherjee B, Heston WD: Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. Clin Cancer Res 2: 1445–51, 1996

    Google Scholar 

  8. Carter RE, Feldman AR, Coyle JT: Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. Proc Natl Acad Sci USA 93: 749–53, 1996

    Google Scholar 

  9. Luthi-Carter R, Barczak AK, Speno H, Coyle JT: Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). J Pharmacol Exp Ther 286: 1020–5, 1998

    Google Scholar 

  10. Barrett AJ: Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NCIUBMB). Enzyme Nomenclature. Recommendations 1992. Suppl 4: corrections and additions (1997). Eur J Biochem 250: 1–6, 1997

    Google Scholar 

  11. Troyer JK, Feng Q, Beckett WGL: Biochemical characterization and mapping of the 7E11-CS.3 epitope of the prostate-specific membrane antigen. Urol Oncol 1: 29–37, 1995

    Google Scholar 

  12. Liu H, Moy P, Kim S, Xia Y, Rajasekaran A, Navarro V, Knudsen B, Bander NH: Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. Cancer Res 57: 3629–34, 1997

    Google Scholar 

  13. Grauer LS, Lawler KD, Marignac JL, Kumar A, Goel AS, Wolfert RL: Identification, purification, and subcellular localization of prostate-specific membrane antigen PSM' protein in the LNCaP prostatic carcinoma cell line. Cancer Res 58: 4787–9, 1998

    Google Scholar 

  14. Murphy GP, Greene TG, Tino WT, Boynton AL, Holmes EH: Isolation and characterization of monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen. J Urol 160: 2396–401, 1998

    Google Scholar 

  15. Wright GL, Haley C, Beckett ML, Schellhammer PF: Expression of prostate-specific membrane antigen in normal, benign, and malignant prostate tissue. Urol Oncol 1: 18–28, 1995

    Google Scholar 

  16. Bostwick DG, Pacelli A, Blute M, Roche P, Murphy GP: Prostate specific membrane antigen expression in prostatic intraepithelial neoplasia and adenocarcinoma: a study of 184 cases. Cancer 82: 2256–61, 1998

    Google Scholar 

  17. Sweat SD, Pacelli, A, Murphy GP, Bostwick DG: Prostate-specific membrane antigen expression is greatest in prostate adenocarcinoma and lymph node metastases. Urology 52: 637–40, 1998

    Google Scholar 

  18. Wright GL, Grob BM, Haley C, Grossman K, Newhall K, Petrylak D, Troyer J, Konchuba A, Schellhammer PF, Moriarty R: Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy. Urology 48: 326–34, 1996

    Google Scholar 

  19. Kawakami M, Nakayama J: Enhanced expression of prostate-specific membrane antigen gene in prostate cancer as revealed by in situ hybridization. Cancer Res 57: 2321–4, 1997

    Google Scholar 

  20. Chang SS, Reuter VE, Heston WD, Hutchinson B, Grauer LS, Gaudin PB: Short term neoadjuvant androgen deprivation therapy does not affect prostate specific membrane antigen expression in prostate tissues. Cancer 88: 407–15, 2000

    Google Scholar 

  21. Troyer JK, Beckett ML, Wright GL Jr: Detection and characterization of the prostate-specific membrane antigen (PSMA) in tissue extracts and body fluids. Int J Cancer 62: 552–8, 1995

    Google Scholar 

  22. Chang SS, Reuter VE, Heston WD, Bander NH, Grauer LS, Gaudin PB: Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. Cancer Res 59: 3192–8, 1999

    Google Scholar 

  23. Chang SS, O'Keefe DS, Bacich DJ, Reuter VE, Heston WDW, Gaudin PB: Prostate-specific membrane antigen (PSMA) is produced in tumor-associated neovasculature. Clin Cancer Res, 1999 (in press)

  24. Silver DA, Pellicer I, Fair WR, Heston WD, Cordon-Cardo C: Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res 3: 81–5, 1997

    Google Scholar 

  25. Elgamal AA, Troychak MJ, Murphy GP: ProstaScint scan may enhance identification of prostate cancer recurrences after prostatectomy, radiation, or hormone therapy: analysis of 136 scans of 100 patients. Prostate 37: 261–9, 1998

    Google Scholar 

  26. Petronis JD, Regan F, Lin K: Indium-111 capromab pendetide (ProstaScint) imaging to detect recurrent and metastatic prostate cancer. Clin Nucl Med 23: 672–7, 1998

    Google Scholar 

  27. Kahn D, Williams RD, Manyak MJ, Haseman MK, Seldin DW, Libertino JA, Maguire RT: 111Indium-capromab pendetide in the evaluation of patients with residual or recurrent prostate cancer after radical prostatectomy. The ProstaScint Study Group. J Urol 159: 2041–6, 1998

    Google Scholar 

  28. Kahn D, Williams RD, Seldin DW, Libertino JA, Hirschhorn M, Dreicer R, Weiner GJ, Bushnell D, Gulfo J: Radioimmunoscintigraphy with 111indium labeled CYT-356 for the detection of occult prostate cancer recurrence. J Urol 152: 1490–5, 1994

    Google Scholar 

  29. Michaels EK, Blend M, Quintana JC: 111Indium-capromab pendetide unexpectedly localizes to renal cell carcinoma. J Urol 161: 597–8, 1999

    Google Scholar 

  30. Israeli RS, Miller WH, Su SL, Powell CT, Fair WR, Samadi DS, Huryk RF, DeBlasio A, Edwards ET, Wise GJ, Heston WDW: Sensitive nested reverse transcription polymerase chain reaction detection of circulating prostatic tumor cells: comparison of prostate-specific membrane antigen and prostate-specific antigen-based assays. Cancer Res 54: 6306–10, 1994

    Google Scholar 

  31. Zhang Y, Zippe CD, Van Lente F, Klein EA, Gupta MK: Combined nested reverse transcription-PCR assay for prostate-specific antigen and prostate-specific membrane antigen in detecting circulating prostatic cells. Clin Cancer Res 3:1215–20, 1997

    Google Scholar 

  32. Ghossein RA, Osman I, Bhattacharya S, Ferrara J, Fazzari M, Cordon-Cardo C, Scher HI: Detection of prostatic specific membrane antigen messenger RNA using immunobead reverse transcriptase polymerase chain reaction. Diagn Mol Pathol 8: 59–65, 1999

    Google Scholar 

  33. Liu H, Rajasekaran AK, Moy P, Xia Y, Kim S, Navarro V, Rahmati R, Bander NH: Constitutive and antibody-induced internalization of prostate-specific membrane antigen. Cancer Res 58: 4055–60, 1998

    Google Scholar 

  34. Eshhar Z, Bach N, Fitzer-Attas CJ, Gross G, Lustgarten J, Waks T, Schindler DG: The T-body approach: potential for cancer immunotherapy. Springer Semin Immunopathol 18: 199–209, 1996

    Google Scholar 

  35. Gong MC, Latouche JB, Krause A, Heston DWD, Bander NH, Sadelain M: Cancer patient T cells genetically targeted to prostate-specific membrane antigen specifically lyse prostate cancer cells and release cytokines in response to prostate-specific membrane antigen. Neoplasia 1: 123–127, 1999

    Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Michael C. Gong, Sam S. Chang & Warren D.W. Heston

  2. Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Michael C. Gong & Michel Sadelain

  3. Department of Urology, New York Presbyterian Hospital-Weill, Medical College of Cornell University, New York, NY, USA

    Neil H. Bander

Authors
  1. Michael C. Gong
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  2. Sam S. Chang
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  4. Neil H. Bander
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  5. Warren D.W. Heston
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Gong, M.C., Chang, S.S., Sadelain, M. et al. Prostate-specific Membrane Antigen (PSMA)-specific Monoclonal Antibodies in the Treatment of Prostate and Other Cancers. Cancer Metastasis Rev 18, 483–490 (1999). https://doi.org/10.1023/A:1006308826967

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