Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies
Under a Creative Commons license
open access
Keywords
Alzheimer's disease
Cerebral hypometabolism
Aβ
Tau
Thiamine
Insulin resistance
Mitochondrial dysfunction
Oxidative stress
Advanced glycation endproducts
Excitotoxicity
Apoptosis
Autophagy
Glycogen synthase kinase 3
Glucagon-like peptide-1
Peroxisome proliferator-activated receptors
Positron emission tomography
Abbreviations
Aβ
β-amyloid
AD
Alzheimer's disease
ADNI
AD neuroimaging initiative
ADP
adenosine driphosphate
AGEs
advanced glycation end products
APOE
apolipoprotein E
APP
amyloid precursor protein
APP-CTFs
APP C-terminal fragments
ATP
adenosine triphosphate
BBB
blood brain barrier
CHEIs
cholinesterase inhibitors
CMRglu
cerebral metabolic rate of glucose
CNS
central nervous system
COX
cytochrome c oxidase
CSF
cerebrospinal fluid
FDG
18F-fluorodeoxyglucose
GLP-1
glucagon-like peptide-1
GLUT
glucose transporter
G6PDH
glucose-6-phosphate dehydrogenase
GSK-3
glycogen synthase kinase-3
IDE
insulin-degrading enzyme
IGF-1
insulin-like growth factor-1
IR
insulin receptor
IRS-1
IR substrate-1
KGDHC
α-ketoglutarate dehydrogenase complex
LTP
long term potentiation
MAPK
mitogen-activated protein kinase
MCI
mild cognitive impairment
MMSE
the Mini-Mental State Examination
MR
magnetic resonance
mTOR
the mammalian target of rapamycin
NFTs
neurofibrillary tangles
NMDAR
N-methyl-D-aspartic acid receptor
NSAID
non-steroidal anti-inflammatory drug
8-OHG
8-hydroxyguanosine
PDHC
pyruvate dehydrogenase complex
PET
positron emission tomography
PiB
11C-Pittsbergh compound
PI3K
phosphatidylinositide 3-kinases
PKM2
pyruvate kinase isozyme type M2
γ-PPAR
γ-peroxisome proliferator-actived receptor
PPP
pentose phosphate pathway
PS1
presenilin-1
RAGE
the receptor of AGEs
rCBF
regional cerebral blood flow
rCMRGlu
regional CMRGlu
ROS
reactive oxygen species
STZ
streptozotocin
TCA
tricarboxylic acid
TD
thiamine deficiency
T1DM
type 1 diabetes mellitus
T2DM
type 2 diabetes mellitus
TDP
thiamine diphosphate
TDPase
thiamine diphosphatase
TGF
transformation growth factor
TMP
thiamine monophosphate
TMPase
thiamine monophosphatase
TPK
thiamine pyrophosphokinase
Cited by (0)
Copyright © 2013 Elsevier Ltd.