Original articlePET/CT imaging: Effect of respiratory motion on apparent myocardial uptake
Section snippets
Study Population
The study group consisted of 22 subjects (10 women and 12 men; mean age, 43.6 ± 15.1 years; mean height, 172.8 ± 8.3 cm; mean weight, 79.1 ± 21.1 kg). The study was performed under a National Institutes of Health–approved protocol. Twenty-five subjects originally entered the protocol, but one was excluded because of scanner malfunction, one because of inadvertent patient motion, and one because of error in following breathing instructions. All patients gave written informed consent. All were
Heart Motion
Consistent with previous reports,14 the heart (and other organs, such as the liver) was displaced between the 3 CT scans. Figure 2 shows a typical coronal view of the same CT slice of a patient. These 2 CT scans were taken during normal breathing at end-expiration and at end-inspiration (mean change in lung volume compared with end-expiration, averaged over all subjects, was 0.52 ± 0.25 L at midvolume and 1.01 ± 0.54 L at end-inspiration). By use of CTEXPIR as a reference, the mean motion of
Discussion
Whether the patient holds or does not hold his or her breath during the CT scan, a fast CT scan freezes the lungs at one point in the respiratory cycle. Because this CT scan does not duplicate the respiratory blurring inherent in the emission data, using the CT scan to perform AC may substantially alter the apparent cardiac FDG uptake. The decrease in the global apparent uptake (ie, averaged over the whole myocardium) when CTMIDVOL or CTINSPIR was used for AC rather than CTEXPIR is probably due
Acknowledgment
The authors have indicated they have no financial conflicts of interest.
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