Original articleOrgan biodistribution and myocardial uptake, washout, and redistribution kinetics of Tc-99m N-DBODC5 when injected during vasodilator stress in canine models of coronary stenoses
Section snippets
Methods
All experiments were performed with the approval of the University of Virginia Animal Care and Use Committee (Charlottesville, Va) in compliance with the position of the American Heart Association on the use of research animals.
Hemodynamic parameters
The hemodynamic parameters from the protocol 1 experiments are summarized in Table 1. Adenosine stress resulted in a fall in mean arterial blood pressure, a rise in heart rate, and an increase in the nonstenotic LCx flow. The stenotic LAD flow fell slightly during the vasodilator infusion. There was a greater than 5-fold flow disparity between the stenotic LAD and normal LCx beds at peak adenosine vasodilatation when the tracers were injected in both Tc-99m N-DBODC5 and Tc-99m sestamibi groups (
Discussion
The quest for better radionuclide perfusion imaging agents, which track myocardial blood flow over a wide range with minimal splanchnic uptake, has been recognized to be of great importance in clinical nuclear cardiology.20 Over the past decade, Tc-99m–labeled myocardial perfusion tracers that use lipophilic, cationic molecules such as Tc-99m sestamibi and Tc-99m tetrofosmin have advanced the field of noninvasive diagnostic evaluation and risk stratification of patients with known or
Acknowledgment
The authors have indicated they have no financial conflicts of interest.
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This experimental study was funded by a generous research grant from Nihon Medi-Physics Co, Ltd.