Original articlesPrognostic value of I-123 15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid myocardial imaging in patients with known or suspected coronary artery disease
Section snippets
Study group
The study group was identified retrospectively by searching the existing databases of the nuclear cardiology laboratories at 4 institutions: Tokyo Medical University, Tokyo; Kyoto Second Red Cross Hospital, Kyoto; Nagoya Daini Red Cross Hospital, Nagoya; and Nippon Medical School, Tokyo, Japan. Patients who underwent BMIPP SPECT for the evaluation of known or suspected CAD because of clinical symptoms, multiple coronary risk factors, or abnormal electrocardiogram after January 1, 1998, and
Overall results
The mean age of 270 patients who completed follow-up was 62 ± 12 years; there were 122 men and 148 women. In the outpatient clinic, SPECT studies were performed in 133 patients, as well as in 137 patients during hospital admission. Of these 137 patients, 54 were admitted on an emergency basis and the remaining 83 were admitted as scheduled. The summed defect score of BMIPP was less than 1 in 132 patients and 1 or greater in the remaining 138 patients, with a median value of 5. Medications at
Discussion
This study demonstrates that an iodinated fatty acid analog, BMIPP, can be used for metabolic imaging of the myocardium at rest to identify a group of patients who are at high risk for subsequent cardiac events. The majority patients in the current patient population (approximately 93%) were those with suspected CAD, excluding those with previous MI. Thus abnormal findings on resting BMIPP myocardial imaging, which were predictive of cardiac events such as cardiac death, nonfatal MI, and
Acknowledgment
We are grateful to Dr Shin-ichiro Kumita of Nippon Medical School, Tokyo; Dr Haruo Hirayama of Nagoya Daini Red Cross Hospital, Nagoya; and Drs Akira Yamashina, Satoshi Hida, Takayuki Morishima, Hidefumi Yanagisawa, Yasuhiro Usui, Katsufumi Harafuji, and Yuko Igarashi of Tokyo Medical University, Tokyo, Japan, for their data acquisition and advice in the preparation of the manuscript. In addition, we wish to thank Professor J. Patrick Barron and Assistant Professor Raoul Breugelmans of the
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