Original articleModel dependence of gated blood pool SPECT ventricular function measurements☆
Section snippets
Patient population
Between September 1, 2001, and February 1, 2003, 486 patients (mean age, 52 ± 17 years; 61% male) were referred to Columbia University, New York, NY, and St Francis Medical Center, Roslyn, NY, for measurement of LVEF by conventional planar-GBP imaging. It was necessary to eliminate 64 studies for technical reasons (given below), leaving 422 studies for subsequent analysis. Specifically, patients were referred for status evaluation after heart transplantation (28%), congestive heart failure
Software region generation
For clinical data, 64 of 486 patients (13%) showed obvious evidence of serious ventricular tracking problems for QBS, regardless of the manner in which algorithms were run (see above). This was consistent with previously reported QBS automation success rates of 70% to 85%.9 To permit a fair and realistic comparison between the two algorithms for clinical images, the questionable cases were eliminated, leaving 422 clinical studies, thereby censoring studies in the same fashion used by previous
Discussion
For clinical data, normal subjects, and MRI and phantom data, QBS and BP-SPECT LV parameters correlated strongly with one another, but all QBS RV relationships were significantly weaker than all QBS LV relationships. QBS algorithm region-generation success rates also were quite similar for all data types. Another finding in common across all data types was that QBS LVEFs and LVEDVs were significantly lower than BP-SPECT values and the other imaging modalities' LV values.
The latter finding was
Acknowledgements
Dr Nichols stands to benefit from sale of software proceeds through marketing arrangements with Syntermed, Inc (Atlanta, Ga), related to the research described in this article. The terms of this arrangement have been reviewed and approved by Columbia University in accordance with its conflict-of-interest practice. The other authors have indicated they have no financial conflicts of interest.
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Supported in part by grants from Siemens Medical Solutions, Inc, Chicago, Ill.