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Micro-imaging of Brain Cancer Radiation Therapy Using Phase-contrast Computed Tomography
2018, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Brain tumor angiogenesis can also be studied using micro-MR angiography, at spatial resolutions of 60 μm and after contrast agent administration (8). Conventional x-ray micro-CT is able to assess the presence of tumors in small animals in vivo (9) after contrast media injection but, otherwise, affords soft tissue sensitivity that is, in absence of contrast agents, rather low. Ex vivo high-resolution MRI after active staining (10) allows for the study of full-organ brain tissue microstructure down to 10- to 25-μm isotropic resolution, quantitative regional volumetric measurements, and the elaboration of several distinct image contrasts, so-called proton stains, to highlight specific anatomic features.
Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in assessing glioblastoma microvasculature
2017, European Journal of RadiologyCitation Excerpt :Therefore, the two contrast agents may have different diffusion behaviors in the examined tissue [18]. Some reports have compared CT and MRI in assessing glioma microvasculature [19–21]. For instance, De Simone M et al. compared cerebral blood volume (CBV) obtained by PCT and first-pass dynamic susceptibility-weighted contrast-enhanced T2-weighted magnetic resonance imaging (DSC-MRI) data, and found that both modalities showed proportional results in CBV assessment of the patients with high grade glioma [19].
Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease
2016, Journal of Neuroscience MethodsCitation Excerpt :Unlike osmium tetroxide and other contrast agents (Metscher, 2009a; White et al., 1976), the iodine technique (Metscher, 2009b; Wong et al., 2013) does not render the tissue unusable after the staining thus allowing continuation of investigation with histology on the same tissue. The micro-CT technique has previously been utilized to image brain diseases (Dobrivojevic et al., 2013; Engelhorn et al., 2009; Park et al., 2014) including recent report with our group showing feasibility in imaging CCM in murine models (Zhou et al., 2016). However, those studies did not include direct validation in relation to histologic morphometry, in part because the osmium staining techniques applied previously do not preserve the histologic structure for direct correlations.
Usefulness of clinical magnetic resonance scanners for imaging experimental changes in laboratory rodents' central nervous system
2012, Polish Annals of MedicineCitation Excerpt :Imaging parameters are presented in Table 1. A clinical Tim Trio scanner (Siemens, Erlangen, Germany) and orbital surface coil with a diameter of 40 mm were used to visualize glioma in rats.8 In this study, 14 female Fisher rats, weighing 150–200 g, were injected with the F98 tumor cell line.
MicroPET/CT imaging of an orthotopic model of human glioblastoma multiforme and evaluation of pulsed low-dose irradiation
2011, International Journal of Radiation Oncology Biology PhysicsAccuracy of image registration between MRI and light microscopy in the ex vivo brain
2011, Magnetic Resonance Imaging