Clinical ResearchCardiomyopathyMicrovascular Function Is Selectively Impaired in Patients With Hypertrophic Cardiomyopathy and Sarcomere Myofilament Gene Mutations
Cardiomyopathy
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Key Words
genetic testing
hypertrophic cardiomyopathy
microvascular dysfunction
positron emission tomography
Abbreviations and Acronyms
CMD
coronary microvascular dysfunction
Dip-MBF
myocardial blood flow following dipyridamole infusion
GLA
galactosidase
HCM
hypertrophic cardiomyopathy
LGE
late gadolinium enhancement
LV
left ventricle/ventricular
MYBPC3
myosin-binding protein C
MYH7
beta-myosin heavy chain
PET
positron emission tomography
VOI
volume of interest
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This work was supported by Ministero Istruzione Università e Ricerca and the European Union (STREP project 241577 “BIG HEART,” 7th European Framework Program). Dr. Ackerman is supported by the Mayo Clinic Windland Smith Rice Comprehensive Sudden Cardiac Death Program. Dr. Cecchi has received honoraria from Genzyme (research grant) and Shire (fees). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.