Clinical Research
Cardiac Imaging
Multislice Computed Tomography and Magnetic Resonance Imaging for the Assessment of Reperfused Acute Myocardial Infarction

https://doi.org/10.1016/j.jacc.2006.02.059Get rights and content
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Objectives

We evaluated the accuracy of in vivo delayed-enhancement multislice computed tomography (DE-MSCT) and delayed-enhancement magnetic resonance imaging (DE-MRI) for the assessment of myocardial infarct size using postmortem triphenyltetrazolium chloride (TTC) pathology as standard of reference.

Background

The diagnostic value of DE-MSCT for the assessment of acute reperfused myocardial infarction is currently unclear.

Methods

In 10 domestic pigs (25 to 30 kg), the circumflex coronary artery was balloon-occluded for 2 h followed by reperfusion. After 5 days (3 to 7 days), DE-MRI (1.5-T) was performed 15 min after administration of 0.2 mmol/kg gadolinium-DTPA using an inversion recovery gradient echo technique. On the same day, DE-MSCT (64-slice) was performed 15 min after administration of 1 gI/kg of iodinated contrast material. One day after imaging, hearts were excised, sectioned in 8 mm short-axis slices, and stained with TTC. Infarct size was defined as the hyperenhanced area on DE-MSCT and DE-MRI images and the TTC-negative area on TTC pathology slices. Infarct size was expressed as percentage of total slice area.

Results

Infarct size determined by DE-MSCT and DE-MRI showed a good correlation with infarct size assessed with TTC pathology (R2= 0.96 [p < 0.001] and R2= 0.93 [p < 0.001], respectively). The correlation between DE-MSCT and DE-MRI was also good (R2= 0.96; p < 0.001). The relative difference in CT attenuation value of infarcted myocardium compared to remote myocardium was 191 ± 18%. The relative MR signal intensity between infarcted myocardium and remote myocardium was 554 ± 156%.

Conclusions

We demonstrated that DE-MSCT can assess acute reperfused myocardial infarction in good agreement with in vivo DE-MRI and TTC pathology.

Abbreviations and Acronyms

CT
computerized tomography
DE-MRI
delayed-enhancement magnetic resonance imaging
DE-MSCT
delayed-enhancement multislice computed tomography
HU
Hounsfield units
TTC
triphenyltetrazolium chloride

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