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Clinical utility of computed tomography and magnetic resonance techniques for noninvasive coronary angiography

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Abstract

Objectives

The purpose of this study was to provide a comprehensive review of the literature relating to electron beam angiography (EBA), magnetic resonance angiography, and spiral computed tomography, currently the three most promising noninvasive methods to visualize obstructions in the coronary tree.

Background

Given the high costs and invasiveness of coronary angiography, there is increased interest in noninvasive coronary angiography, which has made great strides to become a clinically useful tool to augment conventional coronary angiography (CCA).

Methods

MEDLINE searches were performed to include all articles related to noninvasive angiography utilizing either magnetic resonance imaging (MRI), multi-row detector spiral computed tomography (MDCT), and electron beam tomography (EBT). Weighted analysis was performed to define the published sensitivity and specificity for each technique.

Results

Electron beam angiography (EBA) provides an overall sensitivity of 87% and specificity of 91% for the detection of obstructive coronary artery disease (CAD). Four-level MDCT data demonstrated an overall sensitivity of 59% and specificity of 89%, with higher accuracy in two recent studies of 16-level detector devices. Magnetic resonance angiography demonstrated sensitivity for detection of obstructive CAD of 77% and specificity of 71%.

Conclusions

Noninvasive coronary angiography is a rapidly developing technique and currently not an alternative to CCA in all cases. All three methods are currently used clinically in certain centers with appropriate expertise. Selective use should prove both cost-effective and provide a safer, less-invasive method for patients to determine the need for medical versus revascularization therapy.

Abbreviations

3D
three-dimensional
CABG
coronary artery bypass graft
CAC
coronary artery calcifications
CAD
coronary artery disease
CCA
conventional coronary angiography
CT
computed tomography
EBA
electron-beam angiography
EBT
electron-beam tomography
ECG
electrocardiographic
HR
heart rate
MDCT
multi-row-detector spiral computed tomography
MRA
magnetic resonance angiography
MRI
magnetic resonance imaging

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