Cell Metabolism
Volume 21, Issue 2, 3 February 2015, Pages 159-162
Journal home page for Cell Metabolism

Essay
Metformin Action: Concentrations Matter

https://doi.org/10.1016/j.cmet.2015.01.003Get rights and content
Under an Elsevier user license
open archive

Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10–100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.

Cited by (0)